| Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
|---|---|---|---|---|---|---|---|---|---|---|
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0.100 | GeneticVariation | BEFREE | <i>COMT</i> rs4680 (Val158Met) genotype moderates the effect of cannabis on the age of onset of psychosis (AoP). | 29201551 | 2017 |
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0.100 | GeneticVariation | BEFREE | In this study, we aimed to establish the acute effects of administration of cannabis and cocaine on valence-dependent reversal learning as a function of DRD2 Taq1A (rs1800497) and COMT Val108/158Met (rs4680) genotype. | 26572896 | 2016 |
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|
0.100 | GeneticVariation | BEFREE | Epidemiological and retrospective studies suggest a cannabis x catechol-O-methyltransferase (COMT) Val(158)Met interaction effect on development of psychosis. | 27052366 | 2016 |
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0.100 | GeneticVariation | BEFREE | A functional polymorphism in the catechol-O-methyltransferase (COMT) gene (Val(158)Met) appears to influence the immediate cognitive and psychotic effects of cannabis, or ∆(9)-tetrahydrocannabinol (THC), its primary psychoactive ingredient. | 26464454 | 2015 |
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0.100 | GeneticVariation | BEFREE | COMT val158met and 5-HTTLPR genetic polymorphisms moderate executive control in cannabis users. | 23449176 | 2013 |
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0.100 | GeneticVariation | BEFREE | A putative interaction between cannabis and variation at rs4680 within the catechol-methyl-transferase (COMT) gene on psychosis has been reported, but not adequately replicated. | 21947654 | 2011 |
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0.100 | GeneticVariation | BEFREE | The COMT Val158Met genotype seems to modulate the association between cannabis and age at onset of psychotic disorders. | 21231925 | 2011 |
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0.100 | GeneticVariation | BEFREE | Because paranoia is a common feature of stimulant abuse and cocaine-dependent individuals frequently endorse a history of cannabis abuse, we examined whether early cannabis exposure, in conjunction with polymorphic variation in the catechol-O-methyl transferase gene (COMT Val158Met), influences the risk for cocaine-induced paranoia (CIP). | 19944543 | 2010 |
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0.100 | GeneticVariation | BEFREE | The findings confirm that in people with psychometric evidence of psychosis liability, COMT Val(158)Met genotype moderates the association between cannabis and psychotic phenomena in the flow of daily life. | 18808401 | 2009 |
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0.100 | GeneticVariation | BEFREE | We also examined a putative interaction between cannabis and Val(158)Met within the catechol-O-methyltransferase gene (COMT). | 17978319 | 2007 |
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0.100 | GeneticVariation | BEFREE | Observational studies have suggested that psychometric psychosis liability and a functional polymorphism in the catechol-O-methyltransferase (COMT Val(158)Met) gene moderate the psychosis-inducing effect of cannabis. | 16936704 | 2006 |