|
rs4994
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our results suggest that the Trp64Arg mutation is not a major determinant of metabolic disorders (type 2 diabetes, obesity) and chronic complications of type 2 diabetes in a Dutch population.
|
11213599 |
2001 |
|
rs1217691063
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of this work was to evaluate the role of homocysteine, and the MTHFR 677C-->T allele as risk factors for premature coronary artery disease and to analyse the inheritance of this metabolic disorder.
|
11168435 |
2001 |
|
rs8192678
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our findings confirm that sex and age should be considered when investigating the influence of the PPARGC1A Gly482Ser polymorphism on metabolic disease.
|
16474966 |
2006 |
|
rs268
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, the relationships between the Asn291Ser variant and other metabolic diseases such as obesity and high blood pressure were also investigated in this systematic review.
|
16741292 |
2006 |
|
rs1801282
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In conclusion, the PPARG Pro12Ala polymorphism might represent a genetic susceptibility factor for preterm birth and constitute a link between preterm birth and metabolic diseases later in life.
|
17259396 |
2007 |
|
rs1805192
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, the PPARG Pro12Ala polymorphism might represent a genetic susceptibility factor for preterm birth and constitute a link between preterm birth and metabolic diseases later in life.
|
17259396 |
2007 |
|
rs1917760
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We investigated the association of SNP-1308G/T (rs1917760) of DsbA-L gene with metabolic diseases.
|
19225211 |
2009 |
|
rs738409
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The lack of a relationship with visceral obesity and the inverse correlation with CIMT suggest that fatty liver associated with the minor G allele of the PNPLA3 rs738409 polymorphism may not be linked to metabolic disorders.
|
20826584 |
2010 |
|
rs854560
|
|
|
0.020 |
GeneticVariation |
BEFREE |
None of the variants of the Leu55Met PON1 polymorphism was associated with more frequent occurrence of PCOS or metabolic disorders, including insulin resistance.
|
20334584 |
2010 |
|
rs2016520
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The objective of the study was to determine whether rs2016520 or other single-nucleotide polymorphism in the PPARD locus influenced the risk of developing various characteristics of metabolic disease.
|
20200337 |
2010 |
|
rs80356814
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To determine the frequency distribution of LMNA 1908C>T SNP and its association with generalized obesity, abdominal obesity and coexistent metabolic disorders in nondiabetic Asian Indians living in a metropolitan city of north India.
|
21599722 |
2011 |
|
rs738409
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In Inter99, we analyzed associations of rs738409 with components of the WHO-defined metabolic syndrome (n = 5,847) and traits related to metabolic disease (n = 5,663).
|
22792295 |
2012 |
|
rs2241766
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Adiponectin gene polymorphisms (T45G and G276T), adiponectin levels and risk for metabolic diseases in an Arab population.
|
22155316 |
2012 |
|
rs1799904
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings that this novel R80Q (rs1799904) variant both exhibits adverse effects on PC1/3 activity and is prevalent in the population suggests that further biochemical and genetic analysis to assess its contribution to the risk of metabolic disease within the general population is warranted.
|
23383060 |
2013 |
|
rs324420
|
|
|
0.010 |
GeneticVariation |
BEFREE |
It has been demonstrated that the polymorphism 385 C/A of FAAH (fatty acid amide hydrolase) was associated with obesity and metabolic disorders.
|
22609216 |
2013 |
|
rs4986790
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We observed a significant association between D299G polymorphism and metabolic disorders (T2DM and Met-S) risk (OR = 0.566, 95 % CI: 0.347-0.925, p = 0.023) particularly in Caucasians.
|
23275193 |
2013 |
|
rs4988235
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our aim was to test in this study, the association of rs4988235 with BMI and related metabolic diseases, in interaction with dairy product consumption.
|
23647908 |
2013 |
|
rs1801282
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Thus, PPARγ2 rs1801282 polymorphism may play a significant role in the development of metabolic disorders in HIV/HCV coinfected patients, and might have an influence on the cardiovascular risk.
|
25159899 |
2014 |
|
rs11066280
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three gene variants, rs12229654, rs17249754, and rs11066280, were significantly associated with metabolic disorders such as hyperlipidemia and diabetes (P = 0.00071 to 0.0097, respectively).
|
24142389 |
2014 |
|
rs11635252
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, the CRTC3 polymorphism rs3862434 was associated with the plasma level of total cholesterol, and rs11635252 was associated with the risks of overweight and hypertriglyceridemia in a Chinese Han population, which might strengthen our understanding of the complex heredity of metabolic disorders.
|
24264430 |
2014 |
|
rs1431648262
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This perturbation in the desensitization-resensitization cycle of the GIPR variant, revealed in studies of cultured adipocytes, may contribute to the link of the E354Q variant to metabolic disease.
|
25047836 |
2014 |
|
rs17249754
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three gene variants, rs12229654, rs17249754, and rs11066280, were significantly associated with metabolic disorders such as hyperlipidemia and diabetes (P = 0.00071 to 0.0097, respectively).
|
24142389 |
2014 |
|
rs1799983
|
|
|
0.010 |
GeneticVariation |
BEFREE |
ESR1 XbaI and G894T NOS3 polymorphisms may be useful in accessing insulin resistance and type 2 diabetes risks in all women, even before menopause and occurrence of metabolic disease.
|
25077953 |
2014 |
|
rs267606841
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Similarly, the prediction of high damaging behavior, evolutionary conservation and structural destabilization for C574G were proposed as major contributing factors to regulate metabolic disorder underlying tumor calcinosis and hyperostosis-hyperphosphatemia syndrome.
|
24038392 |
2014 |
|
rs3862434
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, the CRTC3 polymorphism rs3862434 was associated with the plasma level of total cholesterol, and rs11635252 was associated with the risks of overweight and hypertriglyceridemia in a Chinese Han population, which might strengthen our understanding of the complex heredity of metabolic disorders.
|
24264430 |
2014 |