|
rs1445081098
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The COMT G158A substitution results in a three- to four-fold decreased activity of the COMT enzyme, which may influence CNS synaptic catecholamine breakdown and could also play a role in MS inflammation.
|
16564429 |
2006 |
|
rs749437638
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Thus, the C677T mutation of the MTHFR gene may influence MS susceptibility.
|
16564429 |
2006 |
|
rs1801275
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We applied the multifactor dimensionality reduction (MDR) test to detect epistasis, and identified single-IL4R(Q576R)- and three-IL4R(Q576R), IL5RA(-80), CD14(-260)- locus association models that predict MS risk with 75-76% accuracy (P<0.01).
|
16625214 |
2006 |
|
rs133945
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We investigated whether the polymorphisms rs133946 and rs133945 in the promoter region of the synapsin III (SYN3) gene are associated with multiple sclerosis in German patients.
|
16972123 |
2006 |
|
rs133946
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We investigated whether the polymorphisms rs133946 and rs133945 in the promoter region of the synapsin III (SYN3) gene are associated with multiple sclerosis in German patients.
|
16972123 |
2006 |
|
rs3087456
|
|
|
0.040 |
GeneticVariation |
BEFREE |
A promoter polymorphism (-168A/G, rs3087456) in the MHC2TA gene was associated with increased susceptibility to rheumatoid arthritis, multiple sclerosis and myocardial infarction in a northern European population.
|
17012290 |
2007 |
|
rs397507444
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Our preliminary findings suggest no association between the MTRR A66G and MTHFR A1298C polymorphisms and MS.
|
17113603 |
2007 |
|
rs1801394
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our preliminary findings suggest no association between the MTRR A66G and MTHFR A1298C polymorphisms and MS.
|
17113603 |
2007 |
|
rs17000900
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The objective of this study was to evaluate the associations between two MXA promoter region single nucleotide polymorphisms (rs2071430 and rs17000900) and the gene expression responses, clinical and MRI phenotypes in IFN-beta treated MS patients.
|
17126411 |
2007 |
|
rs56149945
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Glucocorticoids (GCs) play an important role in controlling chronic inflammatory diseases, like MS. Three polymorphisms in the glucocorticoid receptor (GR) gene (N363S, ER22/23EK and the Bcl I C/G) have been shown to alter glucocorticoid sensitivity, and therefore may influence disease course.
|
17395275 |
2007 |
|
rs1801275
|
|
|
0.040 |
GeneticVariation |
BEFREE |
It was also observed a significant (p=0.016) increase for the IL4R* Q551R CC genotype in AF-MS compared to those of Caucasian ethnicity (AF-MS= 21.62%; CA-MS= 4.35%).
|
17420820 |
2007 |
|
rs132630295
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although the patient met criteria for multiple sclerosis (MS), the proteolipid protein-1 gene (PLP1) contained a mutation in exon 3B (c.409C>T), predicting a tryptophan-for-arginine substitution.
|
17438221 |
2007 |
|
rs113994049
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A patient with trauma-associated onset, and clinical features compatible with multiple sclerosis (MS), was homozygous for G338A mutation of eukaryotic translation initiation factor (eIF2B5).
|
17439913 |
2007 |
|
rs184607650
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A patient with trauma-associated onset, and clinical features compatible with multiple sclerosis (MS), was homozygous for G338A mutation of eukaryotic translation initiation factor (eIF2B5).
|
17439913 |
2007 |
|
rs368243788
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Arg113His mutation of vanishing white matter is not present in multiple sclerosis.
|
17439913 |
2007 |
|
rs662
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In the present study, we have undertaken a case-control study to investigate the possible association of GI A111E, PON1 Q192R and L55M polymorphisms with the risk of MS.
|
17463067 |
2007 |
|
rs854560
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In the present study, we have undertaken a case-control study to investigate the possible association of GI A111E, PON1 Q192R and L55M polymorphisms with the risk of MS.
|
17463067 |
2007 |
|
rs4746
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the present study, we have undertaken a case-control study to investigate the possible association of GI A111E, PON1 Q192R and L55M polymorphisms with the risk of MS.
|
17463067 |
2007 |
|
rs28936
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Application of these methods allowed us to find a significant association between MS and the SNP rs28936 located in the 3' UTR segment of ACCN1 with p = 0.0004 (p = 0.002, after adjusting for multiple testing).
|
17534430 |
2007 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A total of 209 treated MS patients (161 females; 48 males) underwent clinical brain MRI and were genotyped for the BDNF rs6265 Val66Met SNP.
|
17656372 |
2007 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To investigate the association of the rs6265 (Val66Met) single nucleotide polymorphism (SNP) of brain-derived neurotrophic factor (BDNF) with brain morphometry and functional status as measured by quantitative magnetic resonance imaging (MRI) and neurocognitive testing in multiple sclerosis (MS) patients.
|
17656372 |
2007 |
|
rs2104286
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Risk alleles for multiple sclerosis identified by a genomewide study.
|
17660530 |
2007 |
|
rs6897932
|
|
C |
0.900 |
GeneticVariation |
GWASCAT |
Risk alleles for multiple sclerosis identified by a genomewide study.
|
17660530 |
2007 |
|
rs6897932
|
|
C |
0.900 |
GeneticVariation |
GWASDB |
Risk alleles for multiple sclerosis identified by a genomewide study.
|
17660530 |
2007 |
|
rs3135388
|
|
A |
0.890 |
GeneticVariation |
GWASCAT |
Risk alleles for multiple sclerosis identified by a genomewide study.
|
17660530 |
2007 |