|
rs733724
|
|
|
0.800 |
GeneticVariation |
GWASCAT |
A genome-wide association study of brain lesion distribution in multiple sclerosis.
|
23412934 |
2013 |
|
rs733724
|
|
|
0.800 |
GeneticVariation |
GWASDB |
A genome-wide association study of brain lesion distribution in multiple sclerosis.
|
23412934 |
2013 |
|
rs7924357
|
|
|
0.800 |
GeneticVariation |
GWASCAT |
A genome-wide association study of brain lesion distribution in multiple sclerosis.
|
23412934 |
2013 |
|
rs7924357
|
|
|
0.800 |
GeneticVariation |
GWASDB |
A genome-wide association study of brain lesion distribution in multiple sclerosis.
|
23412934 |
2013 |
|
rs9568281
|
|
|
0.800 |
GeneticVariation |
GWASDB |
A genome-wide association study of brain lesion distribution in multiple sclerosis.
|
23412934 |
2013 |
|
rs9568281
|
|
|
0.800 |
GeneticVariation |
GWASCAT |
A genome-wide association study of brain lesion distribution in multiple sclerosis.
|
23412934 |
2013 |
|
rs3136682
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A haplotype in CCL2 and rs3136682 in CCL1 show a protective association to MS, whereas a haplotype in CCL13 is disease predisposing.
|
19865101 |
2010 |
|
rs542002959
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A homozygote p.G587S mutation in NLRP1 has been suggested as potentially causative for the onset of MS in an affected sibling pair, who later developed malignant melanoma.
|
28988323 |
2018 |
|
rs151337641
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A LYST p.V1678A and a PDHA1 p.K387Q mutation were both observed in five MS patients from three separate multi-incident families.
|
28337550 |
2017 |
|
rs6897932
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A meta‑analysis on the association between rs6897932</span> and the risk of MS was also performed.
|
24337176 |
2014 |
|
rs113994049
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A patient with trauma-associated onset, and clinical features compatible with multiple sclerosis (MS), was homozygous for G338A mutation of eukaryotic translation initiation factor (eIF2B5).
|
17439913 |
2007 |
|
rs184607650
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A patient with trauma-associated onset, and clinical features compatible with multiple sclerosis (MS), was homozygous for G338A mutation of eukaryotic translation initiation factor (eIF2B5).
|
17439913 |
2007 |
|
rs1800566
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A polymorphic form of NQO1 (p.P187S) is associated with increased cancer risk and certain neurological disorders (such as multiple sclerosis and Alzheimer´s disease), possibly due to its roles in the antioxidant defence. p.P187S has greatly reduced FAD affinity and stability, due to destabilization of the flavin binding site and the C-terminal domain, which leading to reduced activity and enhanced degradation.
|
31091472 |
2019 |
|
rs1258159645
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A polymorphic form of NQO1 (p.P187S) is associated with increased cancer risk and certain neurological disorders (such as multiple sclerosis and Alzheimer´s disease), possibly due to its roles in the antioxidant defence. p.P187S has greatly reduced FAD affinity and stability, due to destabilization of the flavin binding site and the C-terminal domain, which leading to reduced activity and enhanced degradation.
|
31091472 |
2019 |
|
rs17849781
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A polymorphic form of NQO1 (p.P187S) is associated with increased cancer risk and certain neurological disorders (such as multiple sclerosis and Alzheimer´s disease), possibly due to its roles in the antioxidant defence. p.P187S has greatly reduced FAD affinity and stability, due to destabilization of the flavin binding site and the C-terminal domain, which leading to reduced activity and enhanced degradation.
|
31091472 |
2019 |
|
rs3087456
|
|
|
0.040 |
GeneticVariation |
BEFREE |
A promoter polymorphism (-168A/G, rs3087456) in the MHC2TA gene was associated with increased susceptibility to rheumatoid arthritis, multiple sclerosis and myocardial infarction in a northern European population.
|
17012290 |
2007 |
|
rs3087456
|
|
|
0.040 |
GeneticVariation |
BEFREE |
A promoter SNP -168A→G (rs3087456) has previously been shown to be associated with susceptibility to several immune mediated disorders, including rheumatoid arthritis (RA), multiple sclerosis (MS) and myocardial infarction (MI).
|
20942939 |
2010 |
|
rs34536443
|
|
|
0.730 |
GeneticVariation |
BEFREE |
A rare functional variant within the TYK2 gene (rs34536443) has been reported as protective in multiple sclerosis (MS) in recent studies.
|
19888296 |
2010 |
|
rs1109670
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A recent genome-wide association study conducted on MS identified new biallelic markers outside the HLA (human leucocyte antigen) region involved in disease susceptibility: rs1109670 (DDEF2); rs1458175 (PDZRN4); rs1529316 and rs2049306 (CSMD1); rs16914086 (TBC1D2); rs1755289 (SH3GL2); rs1841770 (ZIC1); rs651477 (EN1); rs7607490 (TRIB2); rs397020 (C20orf46); rs908821 (SLC25A36); rs7672826 (MGC45800) and rs9523762 (GPC5).
|
20944657 |
2011 |
|
rs1458175
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A recent genome-wide association study conducted on MS identified new biallelic markers outside the HLA (human leucocyte antigen) region involved in disease susceptibility: rs1109670 (DDEF2); rs1458175 (PDZRN4); rs1529316 and rs2049306 (CSMD1); rs16914086 (TBC1D2); rs1755289 (SH3GL2); rs1841770 (ZIC1); rs651477 (EN1); rs7607490 (TRIB2); rs397020 (C20orf46); rs908821 (SLC25A36); rs7672826 (MGC45800) and rs9523762 (GPC5).
|
20944657 |
2011 |
|
rs1529316
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A recent genome-wide association study conducted on MS identified new biallelic markers outside the HLA (human leucocyte antigen) region involved in disease susceptibility: rs1109670 (DDEF2); rs1458175 (PDZRN4); rs1529316 and rs2049306 (CSMD1); rs16914086 (TBC1D2); rs1755289 (SH3GL2); rs1841770 (ZIC1); rs651477 (EN1); rs7607490 (TRIB2); rs397020 (C20orf46); rs908821 (SLC25A36); rs7672826 (MGC45800) and rs9523762 (GPC5).
|
20944657 |
2011 |
|
rs2049306
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A recent genome-wide association study conducted on MS identified new biallelic markers outside the HLA (human leucocyte antigen) region involved in disease susceptibility: rs1109670 (DDEF2); rs1458175 (PDZRN4); rs1529316 and rs2049306 (CSMD1); rs16914086 (TBC1D2); rs1755289 (SH3GL2); rs1841770 (ZIC1); rs651477 (EN1); rs7607490 (TRIB2); rs397020 (C20orf46); rs908821 (SLC25A36); rs7672826 (MGC45800) and rs9523762 (GPC5).
|
20944657 |
2011 |
|
rs16914086
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A recent genome-wide association study conducted on MS identified new biallelic markers outside the HLA (human leucocyte antigen) region involved in disease susceptibility: rs1109670 (DDEF2); rs1458175 (PDZRN4); rs1529316 and rs2049306 (CSMD1); rs16914086 (TBC1D2); rs1755289 (SH3GL2); rs1841770 (ZIC1); rs651477 (EN1); rs7607490 (TRIB2); rs397020 (C20orf46); rs908821 (SLC25A36); rs7672826 (MGC45800) and rs9523762 (GPC5).
|
20944657 |
2011 |
|
rs1755289
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A recent genome-wide association study conducted on MS identified new biallelic markers outside the HLA (human leucocyte antigen) region involved in disease susceptibility: rs1109670 (DDEF2); rs1458175 (PDZRN4); rs1529316 and rs2049306 (CSMD1); rs16914086 (TBC1D2); rs1755289 (SH3GL2); rs1841770 (ZIC1); rs651477 (EN1); rs7607490 (TRIB2); rs397020 (C20orf46); rs908821 (SLC25A36); rs7672826 (MGC45800) and rs9523762 (GPC5).
|
20944657 |
2011 |
|
rs1841770
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A recent genome-wide association study conducted on MS identified new biallelic markers outside the HLA (human leucocyte antigen) region involved in disease susceptibility: rs1109670 (DDEF2); rs1458175 (PDZRN4); rs1529316 and rs2049306 (CSMD1); rs16914086 (TBC1D2); rs1755289 (SH3GL2); rs1841770 (ZIC1); rs651477 (EN1); rs7607490 (TRIB2); rs397020 (C20orf46); rs908821 (SLC25A36); rs7672826 (MGC45800) and rs9523762 (GPC5).
|
20944657 |
2011 |