The -1562C>T or R2</span>79Q polymorphism of MMP-9 gene and smoking have a synergistic effect and are significantly associated with the risk of MI in Chinese Uighur population, respectively.
Multiple logistic analysis was performed between MI patients and controls to estimate the risk, and after adjusting for identified risk factors, the CT + TT genotypes of MMP9 rs3918242 were found to be significantly associated with increased risk of developing MI than those with the CC genotype (OR = 2.88, P < 0.01).
Moreover, we also found that there is a statistically significant association between rs3918242 polymorphism and myocardial infarction (MI) in Asians with allelic model (OR 1.66; 95% CI 1.29-2.14; <i>p</i> < 0.0001), recessive model (OR 2.29; 95% CI 1.44-3.63; <i>p</i> = 0.004), and dominant (OR 1.74; 95% CI 1.29-2.35; <i>p</i> = 0.0003) model.