rs1057519903
|
|
|
0.100 |
GeneticVariation |
BEFREE |
As compared to H3 K27M-wildtype tumo</span>rs, there were no differences in age at diagnosis, sex, tumor grade, contrast enhancement on MRI, extent of resection, or treatment received.
|
30864101 |
2019 |
rs1057519903
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We demonstrate in this first series of midline GGs that the H3 K27M mutation can occur in association with the BRAF V600E mutation in grade I glioneuronal tumors.
|
27984673 |
2018 |
rs1057519903
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found 56 H3.3 K27M</span>-mutant tumors (66%), 6 H3.1 K27M-mutant tumors (7%), and 23 H3-wildtype tumors (27%).
|
29016894 |
2018 |
rs1057519903
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Histologically, the tumor was considered to be glioblastoma; however, a part of the tumor exhibiting low proliferative activity appeared to be consistent with long-standing H3 K27M-mutant tumors in the literature.Another case was a 69-year-old male.
|
28547652 |
2017 |
rs1057519903
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Molecular diagnosis of tumor tissue obtained at first and second surgeries revealed H3F3A K27M mutation in both primary and secondary specimens.
|
27392443 |
2016 |
rs1057519903
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Patients with tumours harbouring a K27M mutation in H3.3 (H3F3A) did not respond clinically to radiotherapy as well, relapsed significantly earlier and exhibited more metastatic recurrences than those in H3.1 (HIST1H3B/C).
|
26399631 |
2015 |
rs1057519903
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We only identified H3F3A K27M in 2 of 34 cases (5.9%), with both tumors located in the posterior fossa.
|
25231549 |
2015 |
rs1057519903
|
|
|
0.100 |
GeneticVariation |
BEFREE |
One thalamic tumour had an H3F3A p.K27M.
|
24127995 |
2014 |
rs1057519903
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We identified an increased number of iCNA in older children compared to infants, and increased iCNA in H3F3A K27M mutant tumours compared to G34R/V and wild-type.
|
24548782 |
2014 |
rs1057519903
|
|
|
0.100 |
GeneticVariation |
BEFREE |
None of the other tumor entities showed H3F3A K27M mutation.
|
23429371 |
2013 |
rs1057519903
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Evaluation of histone 3 lysine 27 trimethylation (H3K27me3) and enhancer of Zest 2 (EZH2) in pediatric glial and glioneuronal tumors shows decreased H3K27me3 in H3F3A K27M mutant glioblastomas.
|
23414300 |
2013 |