| Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
|---|---|---|---|---|---|---|---|---|---|---|
|
C | 0.700 | GeneticVariation | CLINVAR | Characterisation of the novel deleterious RAD51C p.Arg312Trp variant and prioritisation criteria for functional analysis of RAD51C missense changes. | 28829762 | 2017 |
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C | 0.700 | GeneticVariation | CLINVAR | Trans-dichlorooxovandium (IV) complex as a novel photoinducible DNA interstrand crosslinker for cancer therapy. | 26678223 | 2016 |
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|
C | 0.700 | GeneticVariation | CLINVAR | Mammalian RAD51 paralogs protect nascent DNA at stalled forks and mediate replication restart. | 26354865 | 2015 |
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|
C | 0.700 | GeneticVariation | CLINVAR | Genetic testing for RAD51C mutations: in the clinic and community. | 25470109 | 2015 |
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|
C | 0.700 | GeneticVariation | CLINVAR | Enhanced non-homologous end joining contributes toward synthetic lethality of pathological RAD51C mutants with poly (ADP-ribose) polymerase. | 25292178 | 2015 |
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|
C | 0.700 | GeneticVariation | CLINVAR | Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair. | 24141787 | 2014 |
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|
C | 0.700 | GeneticVariation | CLINVAR | Pathological features of breast and ovarian cancers in RAD51C germline mutation carriers. | 24993905 | 2014 |
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|
C | 0.700 | GeneticVariation | CLINVAR | ATM- and ATR-mediated phosphorylation of XRCC3 regulates DNA double-strand break-induced checkpoint activation and repair. | 23438602 | 2013 |
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|
C | 0.700 | GeneticVariation | CLINVAR | Distinct roles of FANCO/RAD51C protein in DNA damage signaling and repair: implications for Fanconi anemia and breast cancer susceptibility. | 22167183 | 2012 |
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C | 0.700 | GeneticVariation | CLINVAR | Predominance of pathogenic missense variants in the RAD51C gene occurring in breast and ovarian cancer families. | 22451500 | 2012 |
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|
C | 0.700 | GeneticVariation | CLINVAR | Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene. | 20400964 | 2010 |