| Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
|---|---|---|---|---|---|---|---|---|---|---|
|
T | 0.700 | GeneticVariation | CLINVAR | Surveillance in Germline TP53 Mutation Carriers Utilizing Whole-Body Magnetic Resonance Imaging. | 28772290 | 2017 |
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|
T | 0.700 | GeneticVariation | CLINVAR | Germline Mutations in Cancer Susceptibility Genes in a Large Series of Unselected Breast Cancer Patients. | 28724667 | 2017 |
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|
T | 0.700 | GeneticVariation | CLINVAR | Deleterious Germline Mutations in Patients With Apparently Sporadic Pancreatic Adenocarcinoma. | 28767289 | 2017 |
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|
T | 0.700 | GeneticVariation | CLINVAR | Prevalence of germline TP53 mutations in a prospective series of unselected patients with adrenocortical carcinoma. | 23175693 | 2013 |
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|
T | 0.700 | GeneticVariation | CLINVAR | Dominant-negative features of mutant TP53 in germline carriers have limited impact on cancer outcomes. | 21343334 | 2011 |
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|
T | 0.700 | GeneticVariation | CLINVAR | DNA binding cooperativity of p53 modulates the decision between cell-cycle arrest and apoptosis. | 20471942 | 2010 |
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|
T | 0.700 | GeneticVariation | CLINVAR | Analysis of the DNA-binding activity of p53 mutants using functional protein microarrays and its relationship to transcriptional activation. | 20128691 | 2010 |
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|
T | 0.700 | GeneticVariation | CLINVAR | Radio-induced malignancies after breast cancer postoperative radiotherapy in patients with Li-Fraumeni syndrome. | 21059199 | 2010 |
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|
T | 0.700 | GeneticVariation | CLINVAR | Identification of human p53 mutations with differential effects on the bax and p21 promoters using functional assays in yeast. | 9546439 | 1998 |
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T | 0.700 | GeneticVariation | CLINVAR | The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway. | 8675009 | 1996 |
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T | 0.700 | GeneticVariation | CLINVAR | Screening for germ line TP53 mutations in breast cancer patients. | 1591732 | 1992 |
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|
T | 0.700 | GeneticVariation | CLINVAR | Germ-line mutations of the p53 tumor suppressor gene in patients with high risk for cancer inactivate the p53 protein. | 1631137 | 1992 |