| Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
|---|---|---|---|---|---|---|---|---|---|---|
|
0.100 | GeneticVariation | BEFREE | Significant associations were found with binary obesity status for rs6232 (OR = 1.15, 95% CI 1.06-1.24, P = 6.08 × 10(-6)) and rs6234/rs6235 (OR = 1.07, 95% CI 1.04-1.10, P = 3.00 × 10(-7)). | 25784503 | 2015 |
||||
|
0.100 | GeneticVariation | BEFREE | Furthermore, PCSK1 rs6235 risk allele was related to Adv36 seropositivity (chi(2)=6.85, p=0.033) in overweight/obese subgroup. | 26680480 | 2015 |
||||
|
0.100 | GeneticVariation | BEFREE | Our data revealed no association of PCSK1 rs6235 with the risk of obesity or overweight in the complete subjects. | 24140494 | 2014 |
||||
|
0.100 | GeneticVariation | BEFREE | No difference was found in the association with different obesity grades, and no association of PCSK1 rs6234-rs6235</span> with obesity was identified in Asian populations. | 25355447 | 2014 |
||||
|
0.100 | GeneticVariation | BEFREE | These results indicate that common PCSK1 variants (notably rs6232 and rs6235) contribute modestly to obesity in multi-ethnic American population. | 23451278 | 2013 |
||||
|
0.100 | GeneticVariation | BEFREE | We studied the association of the PCSK1 single-nucleotide polymorphism (SNP) rs6235 (encoding an S690T substitution) with essential hypertension (EH), obesity and related traits in the Han Chinese population. | 22592666 | 2012 |
||||
|
0.100 | GeneticVariation | BEFREE | In contrast, rs6235 showed no significant association with obesity or with glucose homeostasis parameters in any group. | 22737226 | 2012 |
||||
|
0.100 | GeneticVariation | BEFREE | Common single nucleotide polymorphisms (SNPs) within this gene, rs6232 and rs6235, are associated with obesity. | 20534142 | 2010 |
||||
|
0.100 | GeneticVariation | BEFREE | In conclusion, our data suggest that the PCSK1 rs6232 and rs6235 SNPs are not major contributors to common obesity in the general population. | 19528091 | 2009 |
||||
|
0.100 | GeneticVariation | BEFREE | The nonsynonymous variants rs6232, encoding N221D, and rs6234-rs6235, encoding the Q665E-S690T pair, were consistently associated with obesity in adults and children (P = 7.27 x 10(-8) and P = 2.31 x 10(-12), respectively). | 18604207 | 2008 |