|
rs200750564
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs121918346
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The phenotypes varied significantly in cases with heterozygous T54A polymorphism, ranging from hypospermatogenesis and maturation arrest to Sertoli cell-only syndrome.
|
12414900 |
2002 |
|
rs121918346
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our results show that the T54A polymorphism in DAZL has no major role in Japanese males with azoospermia or oligozoospermia.
|
16123080 |
2005 |
|
rs104893837
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A homozygous R262Q mutation in the gonadotropin-releasing hormone receptor presenting as constitutional delay of growth and puberty with subsequent borderline oligospermia.
|
16968799 |
2006 |
|
rs144848
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The results of this study suggested that the polymorphism N372H in BRCA2 gene may be associated with idiopathic male infertility with azoospermia or severe oligozoospermia.
|
16257105 |
2006 |
|
rs1217691063
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Single nucleotide polymorphism C677T in the methylenetetrahydrofolate reductase gene might be a genetic risk factor for infertility for Chinese men with azoospermia or severe oligozoospermia.
|
16888682 |
2007 |
|
rs2228000
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Increased risk of idiopathic azoospermia, but not oligozoospermia was associated with the XPC variant genotypes of Ala499Val (C>T) [adjusted odds ratio (OR) = 1.67, 95% confidence interval (CI) = 1.04-2.68 for CT heterozygote and adjusted OR = 2.03, 95% CI = 1.10-3.75 for TT homozygote] compared with CC homozygous wide-type.
|
18067564 |
2009 |
|
rs2075789
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The role of MSH5 C85T and MLH3 C2531T polymorphisms in the risk of male infertility with azoospermia or severe oligozoospermia.
|
19808033 |
2010 |
|
rs6166
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In the present study, the common G-29A, A919G, and A2039G polymorphisms in the FSHR gene were analysed in 150 (36 non-obstructive azoospermia and 114 individuals with oligozoospermia) patients and 208 normozoospermic men.
|
20170288 |
2010 |
|
rs11703684
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The variant-containing genotypes of HIWI2 rs508485 exhibited a significantly increased risk, with an odds ratios (OR) of 1.49 [95% confidence interval (CI), 1.02-2.18], and individuals with HIWI3 non-synonymous rs11703684 variant genotypes exhibited a significantly reduced oligozoospermia risk (OR = 0.70; 95% CI, 0.49-1.00).
|
20940137 |
2010 |
|
rs175080
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The role of MSH5 C85T and MLH3 C2531T polymorphisms in the risk of male infertility with azoospermia or severe oligozoospermia.
|
19808033 |
2010 |
|
rs508485
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The variant-containing genotypes of HIWI2 rs508485 exhibited a significantly increased risk, with an odds ratios (OR) of 1.49 [95% confidence interval (CI), 1.02-2.18], and individuals with HIWI3 non-synonymous rs11703684 variant genotypes exhibited a significantly reduced oligozoospermia risk (OR = 0.70; 95% CI, 0.49-1.00).
|
20940137 |
2010 |
|
rs1217691063
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The objective of this study was to analyze the distribution of the methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms in idiopathic infertile Brazilian patients with nonobstructive azoospermia (NOA) or severe oligozoospermia and fertile Brazilian men as controls to explore the possible association of these polymorphisms and male infertility.
|
21138341 |
2011 |
|
rs397507444
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The objective of this study was to analyze the distribution of the methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms in idiopathic infertile Brazilian patients with nonobstructive azoospermia (NOA) or severe oligozoospermia and fertile Brazilian men as controls to explore the possible association of these polymorphisms and male infertility.
|
21138341 |
2011 |
|
rs6166
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In this study, we have evaluated the response of FSH treatment in terms of sperm production on the basis of Ala307Thr-Asn680Ser polymorphisms in the FSHR gene in a group of oligozoospermic subjects with hypospermatogenesis and normal FSH levels.
|
20569270 |
2011 |
|
rs6165
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we have evaluated the response of FSH treatment in terms of sperm production on the basis of Ala307Thr-Asn680Ser polymorphisms in the FSHR gene in a group of oligozoospermic subjects with hypospermatogenesis and normal FSH levels.
|
20569270 |
2011 |
|
rs1217691063
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Influence of methylenetetrahydrofolate reductase C677T gene polymorphisms in Algerian infertile men with azoospermia or severe oligozoospermia.
|
22928696 |
2012 |
|
rs397507444
|
|
|
0.030 |
GeneticVariation |
BEFREE |
However, the homozygous (C/C) A1298C polymorphism of the MTHFR gene was present at a statistically high significance in severe oligozoospermia group compared with controls (OR = 3.372, 95% confidence interval CI = 1.27-8.238; p = 0.01431).
|
22457816 |
2012 |
|
rs2075789
|
|
|
0.020 |
GeneticVariation |
BEFREE |
One intronic SNP in MLH1 (rs4647269) and two non-synonymous SNPs in PMS2 (rs1059060, Ser775Asn) and MSH5 (rs2075789, Pro29Ser) seem to be risk factors for the development of azoospermia or oligozoospermia.
|
22594646 |
2012 |
|
rs4647269
|
|
|
0.020 |
GeneticVariation |
BEFREE |
One intronic SNP in MLH1 (rs4647269) and two non-synonymous SNPs in PMS2 (rs1059060, Ser775Asn) and MSH5 (rs2075789, Pro29Ser) seem to be risk factors for the development of azoospermia or oligozoospermia.
|
22594646 |
2012 |
|
rs1042064
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results demonstrated that rs1042064 of EPHX2 was significantly associated with decreased risk of oligozoospermia (OR=0.65, 95% CI: 0.44-0.98) and asthenospermia (OR=0.66, 95% CI: 0.46-0.94).
|
22986331 |
2012 |
|
rs1059060
|
|
|
0.010 |
GeneticVariation |
BEFREE |
One intronic SNP in MLH1 (rs4647269) and two non-synonymous SNPs in PMS2 (rs1059060, Ser775Asn) and MSH5 (rs2075789, Pro29Ser) seem to be risk factors for the development of azoospermia or oligozoospermia.
|
22594646 |
2012 |
|
rs1248142939
|
|
|
0.010 |
GeneticVariation |
BEFREE |
One intronic SNP in MLH1 (rs4647269) and two non-synonymous SNPs in PMS2 (rs1059060, Ser775Asn) and MSH5 (rs2075789, Pro29Ser) seem to be risk factors for the development of azoospermia or oligozoospermia.
|
22594646 |
2012 |
|
rs17420802
|
|
|
0.010 |
GeneticVariation |
BEFREE |
One intronic SNP in MLH1 (rs4647269) and two non-synonymous SNPs in PMS2 (rs1059060, Ser775Asn) and MSH5 (rs2075789, Pro29Ser) seem to be risk factors for the development of azoospermia or oligozoospermia.
|
22594646 |
2012 |
|
rs188541504
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These results indicated that the polymorphism -9C>T and 368A>G in H2BFWT gene are associated with male infertility with idiopathic azoospermia or oligozoospermia, suggesting that H2BFWT gene might be contribute to susceptibility to spermatogenesis impairment in Chinese population.
|
22509975 |
2012 |