|
rs12742784
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The T allele of the rs12742784 SNP was a protective factor for osteoporosis and hip fracture.
|
31352841 |
2020 |
|
rs10085588
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We provide functional regulatory evidence for the rs10085588, which may be a causal SNP within the 7q21.3 GWAS signal for osteoporosis.
|
30878523 |
2019 |
|
rs1057317
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The regulatory association between rs1057317 polymorphism in TLR4 3'-UTR led to an inhibitory effect on the expression of TLR4 by miR-34a, which may explain the observed association between the polymorphism and the susceptibility to OP.
|
30989725 |
2019 |
|
rs10832915
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<b>Conclusion:</b> In conclusion, the <i>SAA1</i> rs10832915 polymorphism and its haplotypes are associated with osteoporosis, but this finding should be confirmed in large well-designed studies.
|
30737305 |
2019 |
|
rs1219648
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Similarly, CC genotype and C allele frequencies of rs1219648 were detected the significant difference between the case and control groups (<i>P</i><0.01); moreover, it was still significant by the adjustion of clinical features, which indicated that rs1219648 was significantly associated with the risk of osteoporosis occurrence (OR = 2.900, 95% CI = 1.341-6.271; OR = 1.602, 95% CI = 1.126-2.279).
|
31113874 |
2019 |
|
rs140121121
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Seven SNPs, including six tagSNPs in PLS3 and one identified genetic risk factor (rs140121121) for osteoporosis in the RS population, were genotyped in all the participants.
|
30837644 |
2019 |
|
rs1554606
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, no significant correlations were found when analyzing the association of rs1800795 and rs1554606 with OST risk.
|
31301734 |
2019 |
|
rs2069849
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggested that the C allele of rs1800796 and the C allele of rs2069849 of IL-6 gene interaction between rs1800796 and abdominal obesity were all associated with increased OST risk.
|
31301734 |
2019 |
|
rs2229579
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, no significant correlations were found when analyzing the association of rs4237 and rs2229579 with OP risk.
|
31832174 |
2019 |
|
rs2297480
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Women with TT genotype in FDPS rs2297480 had significantly lower bone mineral density values in the lumbar spine and total hip, and the presence of the T allele was significantly associated with the osteoporosis.
|
31774873 |
2019 |
|
rs2420946
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Besides, the significant interaction of <i>FGFR2</i> polymorphisms with drinking status in osteoporosis was also found (<i>P</i><0.05), especially rs2981579.<b>Conclusion:</b><i>FGFR2</i> rs2420946 and rs1219648 polymorphisms may be the risk factor of osteoporosis in Chinese population.
|
31113874 |
2019 |
|
rs28377268
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The study aimed at investigating the relationships of rs3755955 and rs6831280 in the <i>IDUA</i> gene and rs28377268 in the <i>PTCH1</i> gene with bone mineral density (BMD), bone turnover markers (BTMs), and fractures in the elderly Chinese subjects with OP.
|
31275456 |
2019 |
|
rs2981579
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Besides, the significant interaction of <i>FGFR2</i> polymorphisms with drinking status in osteoporosis was also found (<i>P</i><0.05), especially rs2981579.<b>Conclusion:</b><i>FGFR2</i> rs2420946 and rs1219648 polymorphisms may be the risk factor of osteoporosis in Chinese population.
|
31113874 |
2019 |
|
rs312009
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of the study was to evaluate the frequency of genotypes and alleles of single nucleotide polymorphism (SNP) rs4988321 and rs312009 of LRP5 in Polish postmenopausal women with osteopenia (n = 109) and osteoporosis (n = 333).
|
29963786 |
2019 |
|
rs34920465
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study discovers the critical role of ZBTB40 and lncRNA ZBTB40-IT1 in bone metabolism, and provides a mechanistic basis for osteoporosis GWAS lead SNPs rs34920465 and rs6426749.
|
30661131 |
2019 |
|
rs3755955
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The study aimed at investigating the relationships of rs3755955 and rs6831280 in the <i>IDUA</i> gene and rs28377268 in the <i>PTCH1</i> gene with bone mineral density (BMD), bone turnover markers (BTMs), and fractures in the elderly Chinese subjects with OP.
|
31275456 |
2019 |
|
rs6831280
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The study aimed at investigating the relationships of rs3755955 and rs6831280 in the <i>IDUA</i> gene and rs28377268 in the <i>PTCH1</i> gene with bone mineral density (BMD), bone turnover markers (BTMs), and fractures in the elderly Chinese subjects with OP.
|
31275456 |
2019 |
|
rs700518
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The analysis of the CYP19A1 rs700518 polymorphism showed that heterozygotes were more common in the group with osteoporosis (58.3%) than in the control group (52.8%).
|
30855728 |
2019 |
|
rs731236
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, VDR gene <i>ApaI</i> (rs7975232), <i>BsmI</i> (rs 1544410) and <i>TaqI</i> (rs731236) genotypes were compared in men with osteoporosis and male controls.
|
31448632 |
2019 |
|
rs749292
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The analysis of the CYP19A1 rs749292 polymorphism showed that there were no statistically significant differences in the distribution of genotypes between the study groups with osteoporosis and osteopenia and the control group.
|
30855728 |
2019 |
|
rs1256044
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs1256044 polymorphism in the ESR2 gene and the risk for osteoporosis in Polish postmenopausal women.
|
29320918 |
2018 |
|
rs1473
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified seven potentially pleiotropic loci-rs3759579 (MARK3), rs2178950 (TRPS1), rs1473 (PUM1), rs9825174 (XXYLT1), rs2047937 (ZNF423), rs17277372 (DNM3), and rs335170 (PRDM6)-associated with osteoporosis and obesity.
|
29145611 |
2018 |
|
rs17277372
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified seven potentially pleiotropic loci-rs3759579 (MARK3), rs2178950 (TRPS1), rs1473 (PUM1), rs9825174 (XXYLT1), rs2047937 (ZNF423), rs17277372 (DNM3), and rs335170 (PRDM6)-associated with osteoporosis and obesity.
|
29145611 |
2018 |
|
rs2047937
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified seven potentially pleiotropic loci-rs3759579 (MARK3), rs2178950 (TRPS1), rs1473 (PUM1), rs9825174 (XXYLT1), rs2047937 (ZNF423), rs17277372 (DNM3), and rs335170 (PRDM6)-associated with osteoporosis and obesity.
|
29145611 |
2018 |
|
rs2178950
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified seven potentially pleiotropic loci-rs3759579 (MARK3), rs2178950 (TRPS1), rs1473 (PUM1), rs9825174 (XXYLT1), rs2047937 (ZNF423), rs17277372 (DNM3), and rs335170 (PRDM6)-associated with osteoporosis and obesity.
|
29145611 |
2018 |