DisGeNET - a database of gene-disease associations

Parkinson Disease, C0030567

Gene: BDNF-AS ×

Source: BEFREE ×

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _v

DPI _v

pLI

EI _vda

EL _gda

Score _vda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Variant

Gene

Risk Allele

Score _vda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

dbSNP:

rs759834365

BDNF ; BDNF-AS

0.100

GeneticVariation

BEFREE

BDNF Val66Met polymorphism is associated with cognitive impairment in Italian patients with Parkinson's disease.

19538209

2009

dbSNP:

rs6265

BDNF ; BDNF-AS

0.100

GeneticVariation

BEFREE

This study examines whether BDNF V66M (c.196 G --> A) or NR4A2 IVS6 +18insG polymorphism is associated with the risk of Taiwanese PD and the age of onset using a case-control study.

17427185

2007

dbSNP:

rs759834365

BDNF ; BDNF-AS

0.100

GeneticVariation

BEFREE

This study examines whether BDNF V66M (c.196 G --> A) or NR4A2 IVS6 +18insG polymorphism is associated with the risk of Taiwanese PD and the age of onset using a case-control study.

17427185

2007

dbSNP:

rs6265

BDNF ; BDNF-AS

0.100

GeneticVariation

BEFREE

To date, there have been several conflicting reports on the correlation between AD or PD and Val66Met or C270T polymorphism in the BDNF promoter region, although no data on this relationship have been published with respect to dementia with Lewy bodies (DLB).

16899999

2006

dbSNP:

rs6265

BDNF ; BDNF-AS

0.100

GeneticVariation

BEFREE

No association between the brain-derived neurotrophic factor 196 G>A or 270 C>T polymorphisms and Alzheimer's or Parkinson's disease.

16565926

2006

dbSNP:

rs746682028

BDNF ; BDNF-AS

0.100

GeneticVariation

BEFREE

No association between the brain-derived neurotrophic factor 196 G>A or 270 C>T polymorphisms and Alzheimer's or Parkinson's disease.

16565926

2006

dbSNP:

rs759834365

BDNF ; BDNF-AS

0.100

GeneticVariation

BEFREE

16899999

2006

dbSNP:

rs759834365

BDNF ; BDNF-AS

0.100

GeneticVariation

BEFREE

No association between the brain-derived neurotrophic factor 196 G>A or 270 C>T polymorphisms and Alzheimer's or Parkinson's disease.

16565926

2006

dbSNP:

rs6265

BDNF ; BDNF-AS

0.100

GeneticVariation

BEFREE

Overall, the meta-analysis of the allele contrast (A vs G) suggested large heterogeneity between studies (P=0.07, I2 =51%) and no association between G196A and the risk of developing PD: random effects odds ratio (OR)=1.00 [95% CI (0.85, 1.18)].

16172806

2005

dbSNP:

rs746682028

BDNF ; BDNF-AS

0.100

GeneticVariation

BEFREE

16172806

2005

dbSNP:

rs759834365

BDNF ; BDNF-AS

0.100

GeneticVariation

BEFREE

16172806

2005

dbSNP:

rs6265

BDNF ; BDNF-AS

0.100

GeneticVariation

BEFREE

We estimated and compared the haplotype frequencies between C270T and G196A markers in PD and controls that was positive (p = 0.0019).

15120095

2004

dbSNP:

rs746682028

BDNF ; BDNF-AS

0.100

GeneticVariation

BEFREE

We estimated and compared the haplotype frequencies between C270T and G196A markers in PD and controls that was positive (p = 0.0019).

15120095

2004

dbSNP:

rs759834365

BDNF ; BDNF-AS

0.100

GeneticVariation

BEFREE

We estimated and compared the haplotype frequencies between C270T and G196A markers in PD and controls that was positive (p = 0.0019).

15120095

2004

dbSNP:

rs6265

BDNF ; BDNF-AS

0.100

GeneticVariation

BEFREE

Thus, our negative findings suggest that it is unlikely that the BDNF Val66Met polymorphism plays a major role in the pathogenesis of PD in the Chinese population.

14642442

2003

dbSNP:

rs759834365

BDNF ; BDNF-AS

0.100

GeneticVariation

BEFREE

Thus, our negative findings suggest that it is unlikely that the BDNF Val66Met polymorphism plays a major role in the pathogenesis of PD in the Chinese population.

14642442

2003

dbSNP:

rs6265

BDNF ; BDNF-AS

0.100

GeneticVariation

BEFREE

We found that homozygosity for the V66M polymorphism of the brain-derived neurotrophic factor (BDNF) gene occurs more frequently in patients with Parkinson's disease than in unaffected controls (chi(2) = 5.46) and confirmed an association with the S18Y polymorphism of the UCH-L1 gene.

11782995

2002

dbSNP:

rs759834365

BDNF ; BDNF-AS

0.100

GeneticVariation

BEFREE

11782995

2002

dbSNP:

rs764254110

BDNF ; BDNF-AS

0.030

GeneticVariation

BEFREE

Gami-Chunggan Formula Prevents Motor Dysfunction in MPTP/p-Induced and A53T α-Synuclein Overexpressed Parkinson's Disease Mouse Model Though DJ-1 and BDNF Expression.

31555122

2019

dbSNP:

rs764254110

BDNF ; BDNF-AS

0.030

GeneticVariation

BEFREE

FTY720 (fingolimod) reduces synucleinopathy in A53T aSyn mice and motor dysfunction in 6-OHDA and rotenone PD models, but no one has tested FTY720 in mice that develop age-onset PD-like motor problems.

31129200

2019

dbSNP:

rs764254110

BDNF ; BDNF-AS

0.030

GeneticVariation

BEFREE

We previously found that aging A53T transgenic (Tg) mice closely model PD-like ENS aSyn pathology, making them appropriate for testing potential PD therapies.

27528608

2016

dbSNP:

rs893924483

BDNF ; BDNF-AS

0.010

GeneticVariation

BEFREE

To determine whether dopaminergic (rs1076560 DRD2 G > T and rs4680 catechole-o-methyltranspherase (COMT) Val158Met) or brain derived neurotrophic factor (rs6265 BDNF Val66Met) genetic polymorphisms are associated with gait function and medication responsiveness in Parkinson's disease.

29249680

2018

dbSNP:

rs370102323

BDNF ; BDNF-AS

0.010

GeneticVariation

BEFREE

We studied two genetic polymorphisms (240C/T and 480G/A) of the brain-derived neurotrophic factor (BDNF) gene in Japanese patients with Alzheimer's disease (AD, n = 172), Parkinson's disease (PD, n = 327), and multiple system atrophy (MSA, n = 122), as well as controls (n = 275).

15838855

2005