|
rs175174
|
|
|
0.080 |
GeneticVariation |
BEFREE |
We found no allelic- or genotype-wise evidence for an association of the rs175174 SNP with schizophrenia in our overall analysis.
|
20661937 |
2010 |
|
rs175174
|
|
|
0.080 |
GeneticVariation |
BEFREE |
For further support from within the Han Chinese ethnic group, we selected two single nucleotide polymorphisms (SNP) located at the distal 5'-end (rs1633445; intron 10 of HpaII tiny fragments locus 9C, HTF9C) and the intron 4 (rs175174) of ZDHHC8 gene to test if these were associated with schizophrenia in a study sample of Taiwan.
|
18075473 |
2007 |
|
rs175174
|
|
|
0.080 |
GeneticVariation |
BEFREE |
We selected four putative risk variants, residing within these genes, ProDH 1945, ProDH 2026, COMT ValMet and ZDHHC8 rs175174, and studied these in a large family-based schizophrenia association sample of European origin (488 Bulgarian parent-offspring trios).
|
16860541 |
2006 |
|
rs175174
|
|
|
0.080 |
GeneticVariation |
BEFREE |
We examined three SNPs of the ZDHHC8 gene, including rs175174, by case-control association in Japanese patients with BPD (N=172) and controls (N=298) or patients with schizophrenia (N=407) and controls (N=497).
|
16150541 |
2005 |
|
rs175174
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The findings on rs175174 at ZDHHC8 are still far from being conclusive, but evidence for sexual dimorphism is moderate, and our data do not support a significant genetic contribution of rs175174 to the aetiopathogenesis of schizophrenia.
|
16225675 |
2005 |
|
rs175174
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Moreover, a very recent study reported that one single nucleotide polymorphism (SNP: rs175174) in ZDHHC8 might affect the splicing process, the ZDHHC8 knock-out mice showed the gender-specific phenotype, and the transmission disequilibrium test (TDT) using this SNP also showed significant association with human female schizophrenia.
|
15631889 |
2005 |
|
rs175174
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Our data suggest that the reported genetic association by either represents type I error resulting from sampling variance or that rs175174 is in linkage disequilibrium (LD) with the functional variant for schizophrenia and different LD patterns obscure the detection of association.
|
15992527 |
2005 |
|
rs175174
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Our results provided compelling supportive evidence for association of the variants within the ZDHHC8 locus with schizophrenia but revealed different risk allele at SNP rs175174.
|
15489219 |
2004 |