Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
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0.760 | GeneticVariation | BEFREE | The common mutations found to be associated with schizophrenia and MTHFR are A222V, E429A, and R594Q. | 28427558 | 2017 |
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0.760 | GeneticVariation | BEFREE | The investigation of the catechol-O-methyltransferase (COMT-[rs4680]) and methylenetetrahydrofolate reductase (MTHFR-[rs1801133]) polymorphisms' interaction might shed light into the pathogenetic mechanisms of the cognitive dysfunction in schizophrenia. | 23353103 | 2013 |
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0.760 | GeneticVariation | BEFREE | To gain insight into the neural and molecular mechanisms of error processing, we used functional MRI to examine effects of a genetic variant in methylenetetrahydrofolate reductase (MTHFR 677C>T, rs1801133) that increases risk for schizophrenia and that has been specifically associated with increased perseverative errors among patients. | 21980405 | 2011 |
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0.760 | GeneticVariation | GWASDB | Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2. | 22037552 | 2011 |
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0.760 | GeneticVariation | BEFREE | However, since our meta-analysis results demonstrated strong support for association of rs1801133 with schizophrenia, further replication studies based on a gene-wide approach need to be considered. | 20692813 | 2010 |
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0.760 | GeneticVariation | BEFREE | Among the Scandinavian patients the functional MTHFR SNP rs1801133 (C677T) significantly affected age at onset of schizophrenia in a dose-dependent manner (P = 0.0015), with lower age of onset with increasing numbers of the mutant T-allele. | 19746410 | 2010 |
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0.760 | GeneticVariation | BEFREE | A second polymorphism, methylenetetrahydrofolate reductase (MTHFR) 677C --> T (rs1801133), has been associated with overall schizophrenia risk and executive function impairment in patients, and may influence dopamine signaling through mechanisms upstream of COMT effects. | 18988738 | 2008 |