The study aimed to evaluate associations between shoulder pain/disability and seven single nucleotide polymorphisms (SNPs) within five angiogenesis-associated genes: <i>KDR</i> (rs2305948 C>T; rs7667298 C>T), <i>NOS3</i> (rs1549758 C>T), <i>MMP2</i> (rs708269 A>T), <i>THBS2</i> (rs9766678 A>G) and <i>TIMP3</i> (rs5754312 T>A; rs715572 G>A).