Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
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0.090 | GeneticVariation | BEFREE | Interactions between BDNF Val66Met polymorphism and early life stress predict brain and arousal pathways to syndromal depression and anxiety. | 19153574 | 2009 |
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0.090 | GeneticVariation | BEFREE | We examined how genetic (brain-derived neurotrophic factor [BDNF] valine 66 to methionine [Val66Met] and serotonin receptor gene 3A [HTR3A]) and early life stress susceptibility factors interact in predicting electroencephalogram (EEG) asymmetry, emotion-elicited heart rate, and self-reported negativity bias, each correlates of risk for depression. | 20728877 | 2010 |
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0.090 | GeneticVariation | BEFREE | These results suggest that both 5-HTTLPR and BDNF Val66Met moderate the relationship between life stress and rumination. | 21745335 | 2011 |
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0.090 | GeneticVariation | BEFREE | BDNF Val66Met polymorphism is associated with HPA axis reactivity to psychological stress characterized by genotype and gender interactions. | 18990498 | 2009 |
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0.090 | GeneticVariation | BEFREE | The results suggest that the Met allele of BDNF Val66Met significantly moderates the relationship between life stress and depression (P = 0.03). | 24433458 | 2014 |
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0.090 | GeneticVariation | BEFREE | The brain-derived neurotrophic factor gene (BDNF) Val66Met polymorphism and life stress have been associated with negative emotionality (e.g., neuroticism), but relevant evidence is far from unequivocal. | 26738427 | 2016 |
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0.090 | GeneticVariation | BEFREE | This study suggests that the common Val66Met polymorphism of the BDNF gene may modulate the relationship between life stress and calorie intake in subjects at risk for psychosis. | 27629407 | 2018 |
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0.090 | GeneticVariation | BEFREE | Brain-derived neurotrophic factor val66met genotype and early life stress effects upon bipolar course. | 23182421 | 2013 |
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0.090 | GeneticVariation | BEFREE | Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism interacts with gender to influence cortisol responses to mental stress. | 28249185 | 2017 |