rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our data suggests that homozygosity for the MTHFR C677T polymorphism is a risk factor of RVO in addition to arterial hypertension and a family history of stroke.
|
9863710 |
1998 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The C677T MTHFR mutation was found in 19% of patients with stroke, 14% of patients with AVN, and 14% of patients with neither complication (P = NS).
|
9840906 |
1998 |
rs1255283120
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The C1565T GPIIIa mutation was found in 25% of patients with stroke, 14% of patients with AVN, and 18% of patients with neither complication (P = NS).
|
9840906 |
1998 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
According to our results, the C677T mutation does not constitute a major risk factor for transient ischemic attack or minor stroke, even under consideration of other possibly confounding factors that are known to affect plasma homocysteine levels.
|
10360632 |
1999 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The odds ratio of stroke for C677T homozygotes, with other genotypes as a reference group, was 1.59, 95% CI=0.85, 2.97.
|
9974399 |
1999 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There was no difference in the proportion of patients with SCD with or without stroke who were homozygous for the C677T MTHFR mutation (0/11 versus 2/29; Fisher's, P = 1.000).
|
10524453 |
1999 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The prevalence of the homozygous C677T mutation was not significantly higher in the elderly stroke patients (7%) than in the atherosclerotic risk (8%) or healthy elderly control (2%) groups.
|
10408794 |
1999 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
C677T MTHFR mutation and factor V Leiden mutation in patients with TIA/minor stroke: a case-control study.
|
9950259 |
1999 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We therefore investigated a possible role of the MTHFR C677T polymorphism in SS disease patients with stroke.
|
10583261 |
1999 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The odds ratio for stroke was not significantly increased in carriers of the prothrombin mutation (OR 1.2; 95% CI 0.1-10.7), FVL (OR 2.5; 95% CI 0.5-13.5), or the C677T mutation (OR 1.7; 95% CI 0.6-4.5).
|
10365738 |
1999 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We investigated associations between the C677T MTHFR polymorphism, folate levels, total plasma homocysteine, and hematological parameters in 94 patients with cerebrovascular disease (transient ischemic attack/minor stroke) and in 82 healthy subjects.
|
10695265 |
2000 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Moreover, the 677 C-->T genotype is a strong factor for predisposition to hyperhomocysteinemia and recurrent risk of stroke</span> that might also be prevented with folate supplementation.
|
10830195 |
2000 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The roles of ACE D polymorphism and the MTHFR C677T mutation in stroke, should also be taken into consideration in this subgroup of stroke patients.
|
10949530 |
2000 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Fasting total plasma homocysteine (tHcy) concentration, C677T MTHFR genotype, and 844ins68bp CBS genotype were determined in 25 patients with sCAD, 31 patients <45 years of age with non-CAD ischemic stroke, and 36 control subjects.
|
11872884 |
2002 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Genotyping of methylenetetrahydrofolate reductase (MTHFR) C677T gene mutation and brain MRI examination were performed in 1721 subjects free of any history of stroke.
|
12690212 |
2003 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
It is still controversial whether elevated plasma homocysteine and the C677T polymorphism of methylenetetrahydrofolate reductase (MTHFR) gene are risk factors for stroke.
|
12907815 |
2003 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Red cell N5-methyltetrahydrofolate concentrations and C677T methylenetetrahydrofolate reductase genotype in patients with stroke.
|
14693836 |
2004 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The folate-sensitive polymorphism methylenetetrahydrofolate reductase (MTHFR) c. 677 C > T (A222V) referred a non-significant risk of ischemic stroke (odds ratio: 1.20) in all patients, and homozygosity for MTHFR c. 677 C > T was associated with an earlier onset of stroke selectively in patients younger than 60 years (38 +/- 3 years vs. 45 +/- 1 years; P = 0.043).
|
16053469 |
2005 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This indicates that C677T MTHFR mutation is strongly associated with arterial stroke especially in young adults.
|
15613145 |
2005 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Individuals homozygous for the T allele of the MTHFR C677T polymorphism have higher plasma homocysteine concentrations (the phenotype) than those with the CC genotype, which, if pathogenetic, should put them at increased risk of stroke.
|
15652605 |
2005 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A recent study of children demonstrated that the homozygous form of C677T polymorphism occurred two-times as often in those with stroke versus healthy controls.
|
16282888 |
2005 |
rs1801133
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The folate-sensitive polymorphism methylenetetrahydrofolate reductase (MTHFR) c. 677 C > T (A222V) referred a non-significant risk of ischemic stroke (odds ratio: 1.20) in all patients, and homozygosity for MTHFR c. 677 C > T was associated with an earlier onset of stroke selectively in patients younger than 60 years (38 +/- 3 years vs. 45 +/- 1 years; P = 0.043).
|
16053469 |
2005 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Therefore, we examined whether the C677T and A1298C polymorphisms of MTHFR gene are genetic risk factors for both ischemic and hemorrhagic stroke in a Turkish Caucasian population.
|
17113927 |
2006 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The MTHFR C677T genotype has been associated with increased risk of migraine in selected clinical samples and with elevated homocysteine, a risk factor for stroke.
|
16365871 |
2006 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Plasma total homocysteine (tHcy) concentration and the distribution of the C677T genotypes of the methylenetetrahydrofolate reductase gene (MTHFR) were compared in 174 consecutive patients with stroke aged <45 years and 155 age and sex-matched controls.
|
16624841 |
2006 |