|
rs6871626
|
|
|
0.050 |
GeneticVariation |
BEFREE |
We also found that rs6871626 showed a significant association with clinical manifestations of TAK, including increased risk and severity of aortic regurgitation, a representative severe complication of TAK.
|
23830516 |
2013 |
|
rs6871626
|
|
|
0.050 |
GeneticVariation |
BEFREE |
IL12B rs6871626 did not show an association with IBD-TA compared with that with TA without IBD.
|
28449344 |
2017 |
|
rs6871626
|
|
|
0.050 |
GeneticVariation |
BEFREE |
We demonstrated a allele association between the four SNPs of IL12B and TA (rs6871626: OR 1.52, 95% CI 1.26-1.83; rs4921492: OR 1.46, 95% CI 1.21-1.75; rs60689680: OR 1.41, 95% CI 1.17-1.69; rs4921493: OR 1.45, 95% CI 1.21-1.75, all P <sub>c</sub> < 10<sup>- 3</sup> ).
|
28160070 |
2017 |
|
rs56167332
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We also established the genetic association between IL12B and Takayasu arteritis (rs56167332, OR = 1.54, p = 2.18 × 10(-8)).
|
23830517 |
2013 |
|
rs56167332
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Four single nucleotide polymorphisms (SNPs) those locate in the IL12B region (rs56167332), the MLX region (rs665268), the FCGR2A/FCGR3A locus (rs10919543), and the HLA-B/MICA locus (rs12524487), associated with TA in different population, were genotyped in 123 Chinese TA patients and 147 healthy controls from January 2013 to August 2014.
|
26996483 |
2016 |
|
rs2836878
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified genetic susceptibility loci for Takayasu arteritis with a genome-wide level of significance in IL6 (rs2069837) (odds ratio [OR] 2.07, P = 6.70 × 10(-9)), RPS9/LILRB3 (rs11666543) (OR 1.65, P = 2.34 × 10(-8)), and an intergenic locus on chromosome 21q22 (rs2836878) (OR 1.79, P = 3.62 × 10(-10)).
|
25604533 |
2015 |
|
rs4921492
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We demonstrated a allele association between the four SNPs of IL12B and TA (rs6871626: OR 1.52, 95% CI 1.26-1.83; rs4921492: OR 1.46, 95% CI 1.21-1.75; rs60689680: OR 1.41, 95% CI 1.17-1.69; rs4921493: OR 1.45, 95% CI 1.21-1.75, all P <sub>c</sub> < 10<sup>- 3</sup> ).
|
28160070 |
2017 |
|
rs4921493
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We demonstrated a allele association between the four SNPs of IL12B and TA (rs6871626: OR 1.52, 95% CI 1.26-1.83; rs4921492: OR 1.46, 95% CI 1.21-1.75; rs60689680: OR 1.41, 95% CI 1.17-1.69; rs4921493: OR 1.45, 95% CI 1.21-1.75, all P <sub>c</sub> < 10<sup>- 3</sup> ).
|
28160070 |
2017 |
|
rs60689680
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We demonstrated a allele association between the four SNPs of IL12B and TA (rs6871626: OR 1.52, 95% CI 1.26-1.83; rs4921492: OR 1.46, 95% CI 1.21-1.75; rs60689680: OR 1.41, 95% CI 1.17-1.69; rs4921493: OR 1.45, 95% CI 1.21-1.75, all P <sub>c</sub> < 10<sup>- 3</sup> ).
|
28160070 |
2017 |
|
rs9366782
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings indicated that rs12524487 in HLA-B/MICA was a genetic risk factor for TA in a Chinese Han population and rs9366782 in this region was associated with ischemic brain disease in TA but not TA susceptibility.
|
28261975 |
2018 |
|
rs8111
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Identification of Susceptibility Loci in IL6, RPS9/LILRB3, and an Intergenic Locus on Chromosome 21q22 in Takayasu Arteritis in a Genome-Wide Association Study.
|
25604533 |
2015 |
|
rs4410768
|
|
G |
0.700 |
GeneticVariation |
GWASCAT |
Identification of Susceptibility Loci in IL6, RPS9/LILRB3, and an Intergenic Locus on Chromosome 21q22 in Takayasu Arteritis in a Genome-Wide Association Study.
|
25604533 |
2015 |
|
rs1205
|
|
|
0.010 |
GeneticVariation |
BEFREE |
T allele of rs1205 in CRP gene was less frequent in TA.
|
29024426 |
2018 |
|
rs41267090
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Identification of Susceptibility Loci in IL6, RPS9/LILRB3, and an Intergenic Locus on Chromosome 21q22 in Takayasu Arteritis in a Genome-Wide Association Study.
|
25604533 |
2015 |
|
rs7743661
|
|
C |
0.700 |
GeneticVariation |
GWASCAT |
Identification of Susceptibility Loci in IL6, RPS9/LILRB3, and an Intergenic Locus on Chromosome 21q22 in Takayasu Arteritis in a Genome-Wide Association Study.
|
25604533 |
2015 |
|
rs2457837
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Identification of Susceptibility Loci in IL6, RPS9/LILRB3, and an Intergenic Locus on Chromosome 21q22 in Takayasu Arteritis in a Genome-Wide Association Study.
|
25604533 |
2015 |
|
rs117298325
|
|
C |
0.700 |
GeneticVariation |
GWASCAT |
Genetic determinants and an epistasis of LILRA3 and HLA-B*52 in Takayasu arteritis.
|
30498034 |
2018 |
|
rs12111032
|
|
G |
0.700 |
GeneticVariation |
GWASCAT |
Identification of Susceptibility Loci in IL6, RPS9/LILRB3, and an Intergenic Locus on Chromosome 21q22 in Takayasu Arteritis in a Genome-Wide Association Study.
|
25604533 |
2015 |
|
rs1383258
|
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Identification of Susceptibility Loci in IL6, RPS9/LILRB3, and an Intergenic Locus on Chromosome 21q22 in Takayasu Arteritis in a Genome-Wide Association Study.
|
25604533 |
2015 |
|
rs113452171
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Identification of multiple genetic susceptibility loci in Takayasu arteritis.
|
23830517 |
2013 |
|
rs1264457
|
|
|
0.010 |
GeneticVariation |
BEFREE |
sHLA-E level is useful as a biomarker of disease activity and course in TA patients. rs1264457 polymorphism is neither associated with susceptibility nor did it influence sHLA-E levels in TA.
|
28425192 |
2018 |
|
rs582054
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, a trend for IL12A rs582054 and IL23R rs1004819 in association with the TA phenotype was detected.
|
26987707 |
2016 |
|
rs763780
|
|
|
0.010 |
GeneticVariation |
BEFREE |
G allele of rs763780 in IL-17F gene was protectively associated against susceptibility to TA.
|
28438554 |
2018 |
|
rs1004819
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, a trend for IL12A rs582054 and IL23R rs1004819 in association with the TA phenotype was detected.
|
26987707 |
2016 |
|
rs2069837
|
|
|
0.720 |
GeneticVariation |
GWASCAT |
We identified genetic susceptibility loci for Takayasu arteritis with a genome-wide level of significance in IL6 (rs2069837) (odds ratio [OR] 2.07, P = 6.70 × 10(-9)), RPS9/LILRB3 (rs11666543) (OR 1.65, P = 2.34 × 10(-8)), and an intergenic locus on chromosome 21q22 (rs2836878) (OR 1.79, P = 3.62 × 10(-10)).
|
25604533 |
2015 |