Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs113488022
rs113488022
0.100 GeneticVariation BEFREE One hundred and fifty-three thyroid samples obtained by FNA of thyroid nodules from 151 patients were subjected to the analysis of BRAF V600E mutation by direct sequencing. 25194426

2014

dbSNP: rs113488022
rs113488022
0.100 GeneticVariation BEFREE We recommend that patients with a thyroid nodule with any suspicious sonographic feature undergo preoperative BRAF(V600E) testing for risk stratification and to guide the initial surgical approach in PTC. 25337709

2014

dbSNP: rs113488022
rs113488022
0.100 GeneticVariation BEFREE In the management of thyroid nodules with benign cytology but positive BRAF(V600E) mutation, thyroidectomy should be considered in nodules which have 2 or more suspicious US features and are considered discordant on image-cytology correlation. 25616949

2015

dbSNP: rs113488022
rs113488022
0.100 GeneticVariation BEFREE Evaluation of the Real-Q BRAF V600E Detection Assay in Fine-Needle Aspiration Samples of Thyroid Nodules. 25937618

2015

dbSNP: rs113488022
rs113488022
0.100 GeneticVariation BEFREE Of the 56 previous AUS result thyroid nodules with surgical management, BRAF(V600E) mu</span>tation analysis led to therapeutic surgery in 5.4% by decreasing unnecessary diagnostic surgery. 25978151

2015

dbSNP: rs113488022
rs113488022
0.100 GeneticVariation BEFREE The probability of PTC for thyroid nodules with intermediat</span>e-risk (IR) US and atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) FNAB was significantly dependent on BRAF V600E mutation status based on our prediction table (negative, 29.2% vs positive, 87.5%; P < 0.001). 26020381

2015

dbSNP: rs113488022
rs113488022
0.100 GeneticVariation BEFREE Initial clinical experience with BRAF(V600E) mutation analysis of core-needle biopsy specimens from thyroid nodules. 26215382

2016

dbSNP: rs113488022
rs113488022
0.100 GeneticVariation BEFREE For thyroid nodules that were diagnosed cytologically as suspicious for papillary thyroid cancer, univariate pooled sensitivity using FNA and BRAF(V600E) results was 52% (95% confidence interval, 39%-64%). 26232865

2015

dbSNP: rs113488022
rs113488022
0.100 GeneticVariation BEFREE Evaluation of the Anyplex BRAF V600E real-time detection assay using dual-priming oligonucleotide technology in fine-needle aspirates of thyroid nodules. 26354351

2015

dbSNP: rs113488022
rs113488022
0.100 GeneticVariation BEFREE The aim of the study was to determine BRAF T1799A mutation and KRas proto-oncogene mutation, and the analysis of RASSF1A promoter methylation level in cytological material obtained from FNAB specimens of thyroid nodules. 26457492

2015

dbSNP: rs113488022
rs113488022
0.100 GeneticVariation BEFREE BRAF V600E detection is currently used as molecular test to improve the diagnosis of thyroid nodules, yet it lacks sensitivity. 26581891

2015

dbSNP: rs113488022
rs113488022
0.100 GeneticVariation BEFREE Value of TIRADS, BSRTC and FNA-BRAF V600E mutation analysis in differentiating high-risk thyroid nodules. 26597052

2015

dbSNP: rs113488022
rs113488022
0.100 GeneticVariation BEFREE The preoperative knowledge of the V600E mutation status is fundamental to plan total thyroidectomy with certainty and should be part of the decision tree for the management of thyroid nodules. 26854757

2016

dbSNP: rs113488022
rs113488022
0.100 GeneticVariation BEFREE Evaluation of BRAF V600E mutation status combined with cytomorphological features for diagnosis of PTC in cytologically indeterminate thyroid nodules can significantly improve diagnostic accuracy and reduce the number of diagnostic operations (calculator available at www.ptc-calc.we2host.lt). 29566402

2019

dbSNP: rs113488022
rs113488022
0.100 GeneticVariation BEFREE Testing for BRAF (V600E) Mutation in Thyroid Nodules with Fine-Needle Aspiration (FNA) Read as Suspicious for Malignancy (Bethesda V, Thy4, TIR4): a Systematic Review and Meta-analysis. 31811566

2020