Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs121912655
rs121912655
TP53
T 0.700 CausalMutation CLINVAR The Clinical Utility of Next Generation Sequencing Results in a Community-Based Hereditary Cancer Risk Program. 27276934

2017
dbSNP: rs121912655
rs121912655
TP53
T 0.700 CausalMutation CLINVAR Germline TP53 variants and susceptibility to osteosarcoma. 25896519

2015
dbSNP: rs121912655
rs121912655
TP53
T 0.700 CausalMutation CLINVAR Dominant-negative features of mutant TP53 in germline carriers have limited impact on cancer outcomes. 21343334

2011
dbSNP: rs121912655
rs121912655
TP53
T 0.700 CausalMutation CLINVAR Altered-function p53 missense mutations identified in breast cancers can have subtle effects on transactivation. 20407015

2010
dbSNP: rs121912655
rs121912655
TP53
T 0.700 CausalMutation CLINVAR A novel HER2-positive breast cancer phenotype arising from germline TP53 mutations. 20805372

2010
dbSNP: rs121912655
rs121912655
TP53
T 0.700 CausalMutation CLINVAR Beyond BRCA1 and BRCA2 wild-type breast and/or ovarian cancer families: germline mutations in TP53 and PTEN. 19930417

2010
dbSNP: rs121912655
rs121912655
TP53
T 0.700 CausalMutation CLINVAR Radio-induced malignancies after breast cancer postoperative radiotherapy in patients with Li-Fraumeni syndrome. 21059199

2010
dbSNP: rs121912655
rs121912655
TP53
T 0.700 CausalMutation CLINVAR Molecular basis of the Li-Fraumeni syndrome: an update from the French LFS families. 18511570

2008
dbSNP: rs121912655
rs121912655
TP53
T 0.700 CausalMutation CLINVAR p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis. 12726864

2003
dbSNP: rs121912655
rs121912655
TP53
T 0.700 CausalMutation CLINVAR Understanding the function-structure and function-mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis. 12826609

2003
dbSNP: rs121912655
rs121912655
TP53
T 0.700 CausalMutation CLINVAR Characterization of the p53 mutants ability to inhibit p73 beta transactivation using a yeast-based functional assay. 12917626

2003
dbSNP: rs121912655
rs121912655
TP53
T 0.700 CausalMutation CLINVAR p53 mutants can often transactivate promoters containing a p21 but not Bax or PIG3 responsive elements. 11429705

2001
dbSNP: rs121912655
rs121912655
TP53
T 0.700 CausalMutation CLINVAR Astrocytoma and B-cell lymphoma development in a man with a p53 germline mutation. 9839505

1998
dbSNP: rs121912655
rs121912655
TP53
T 0.700 CausalMutation CLINVAR Simple identification of dominant p53 mutants by a yeast functional assay. 9364015

1997
dbSNP: rs121912655
rs121912655
TP53
T 0.700 CausalMutation CLINVAR Germline mutations of the p53 tumor suppressor gene in children with osteosarcoma. 8164043

1994
dbSNP: rs121912655
rs121912655
TP53
T 0.700 CausalMutation CLINVAR Identification of a germ-line mutation in the p53 gene in a patient with an intracranial ependymoma. 1679237

1991
dbSNP: rs121912655
rs121912655
TP53
T 0.700 CausalMutation CLINVAR Mutations in the p53 gene occur in diverse human tumour types. 2531845

1989
dbSNP: rs121912655
rs121912655
TP53
T 0.700 CausalMutation CLINVAR p53: a frequent target for genetic abnormalities in lung cancer. 2554494

1989