|
rs2230926
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The rs2230926 exonic variant was associated with an increased risk for pSS complicated by lymphoma (odds ratio, 3.36 [95% confidence interval, 1.34-8.42], and odds ratio, 3.26 [95% confidence interval, 1.31-8.12], vs controls and pSS patients without lymphoma, respectively; P = .011).
|
24159176 |
2013 |
|
rs2230926
|
|
|
0.030 |
GeneticVariation |
BEFREE |
TNFAIP3 F127C Coding Variation in Greek Primary Sjogren's Syndrome Patients.
|
30662920 |
2018 |
|
rs2230926
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In both cohorts, the rs2230926 missense polymorphism was not associated with pSS.
|
26338037 |
2016 |
|
rs7574865
|
|
|
0.030 |
GeneticVariation |
BEFREE |
To examine the influence of STAT4 rs7574865 gene polymorphism on patients with primary Sjögren's syndrome (SS).
|
20360187 |
2010 |
|
rs7574865
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Our meta-analysis revealed that the STAT4 rs7574865 polymorphism is associated with four autoimmune diseases with systemic pathology, including systemic lupus erythematosus (OR = 1.52; 95% CI = 1.48 - 1.56, P<1.0 × 10(-16)), rheumatoid arthritis (OR = 1.27; 95% CI = 1.21 - 1.33, P < 1.00 × 10(-16)), systemic sclerosis (OR = 1.38; 95% CI = 1.27 - 1.50, P < 1.44 × 10(-14)), and primary Sjogren's syndrome (OR = 1.32; 95% CI = 1.01 - 1.73, P = 4.40 × 10(-2)), while no association was found with type I diabetes, juvenile idiopathic arthritis, ulcerative colitis and Crohn's disease.
|
23628400 |
2013 |
|
rs7574865
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The overall odds ratios for rs7574865 T-allele significantly increased in SLE, RA, T1D, SSc, JIA, and APS (OR = 1.56, 1.25, 1.13, 1.34, 1.25, and 2.15, respectively, P < 0.00001) and in IBD-UC and pSS (OR = 1.11 and 1.33, respectively, P < 0.05).
|
22714917 |
2012 |
|
rs117026326
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The combined analysis identified GTF2I at 7q11.23 (rs117026326: Pcombined = 1.31 × 10(-53), combined odds ratio (ORcombined) = 2.20) as a new susceptibility locus for primary Sjögren's syndrome.
|
24097066 |
2013 |
|
rs117026326
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Genetic variant rs117026326 upstream of the general transcription factor II-I (GTF2I) has been associated with primary Sjögren's syndrome, SLE and RA in East Asian populations.
|
31520790 |
2019 |
|
rs2736340
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our results indicated that the SNPs (rs2736340, rs13277113) of the FAM167A-BLK region, but not the BANK1 SNPs (rs4522865, rs17266594, and rs10516487), were associated with the development of pSS in Han Chinese.
|
23899688 |
2013 |
|
rs2736340
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Stratification analysis by diseases suggested FAM167A-BLK rs2736340 had a positive association with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), systemic sclerosis (SSc) and Kawasaki disease, primary Sjogren's syndrome (pSS), primary antiphosholipid syndrome (APS), and myositis.
|
27105348 |
2016 |
|
rs10516487
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results indicated that the SNPs (rs2736340, rs13277113) of the FAM167A-BLK region, but not the BANK1 SNPs (rs4522865, rs17266594, and rs10516487), were associated with the development of pSS in Han Chinese.
|
23899688 |
2013 |
|
rs10817595
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<i>HIF1A</i> (rs11549465) and <i>AKNA</i> (rs10817595) Gene Polymorphisms Are Associated with Primary Sjögren's Syndrome.
|
28484714 |
2017 |
|
rs10840759
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There is no association between rs10840759 and SLE or primary SS.
|
26429306 |
2015 |
|
rs1143679
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We evaluated case-control association between rs1143679 and ADs (N=18,457) including primary Sjögren's syndrome, systemic sclerosis, multiple sclerosis, rheumatoid arthritis, juvenile idiopathic arthritis, celiac disease, and type-1 diabetes.
|
21840425 |
2012 |
|
rs11549465
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified <i>HIF1A Pro582Ser T</i> allele and <i>C</i>/<i>T</i> genotype as well as <i>AKNA -1372C>A</i> polymorphism A/A genotype as genetic factors associated with pSS.
|
28484714 |
2017 |
|
rs11575837
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We performed a case-control study of genetic polymorphisms of the NCR3/NKp30 gene and found that rs11575837 (G>A) residing in the promoter was associated with reduced gene transcription and function as well as protection to pSS.
|
23884468 |
2013 |
|
rs1217691063
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Αnalysis according to lymphoma subtype revealed increased frequency of c. 677C > T TT genotype and T allele, as well as reduced prevalence of the c. 1298A > C C allele in the pSS non-MALT group compared to controls and patients without NHL.
|
28779180 |
2017 |
|
rs1234313
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In TNFSF4, T allele and TT genotype of rs2205960, and G allele of rs1234313, were associated with pSS (p<0.05); T allele of rs2205960 was correlated with PBC (p<0.05) as a risk factor.
|
23622253 |
2013 |
|
rs12583006
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The low risk pSS group exhibited higher frequency of the minor A allele and AA genotype of the rs12583006 variant compared to HC.
|
23845207 |
2014 |
|
rs13277113
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results indicated that the SNPs (rs2736340, rs13277113) of the FAM167A-BLK region, but not the BANK1 SNPs (rs4522865, rs17266594, and rs10516487), were associated with the development of pSS in Han Chinese.
|
23899688 |
2013 |
|
rs13447
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We show that the p.Arg90His substitution, which is reported to cause reduced reactive oxygen species (ROS) production, predisposes to SLE (odds ratio (OR) = 3.47 in Asians (P<sub>meta</sub> = 3.1 × 10<sup>-104</sup>), OR = 2.61 in European Americans, OR = 2.02 in African Americans) and other autoimmune diseases, including primary Sjögren's syndrome (OR = 2.45 in Chinese, OR = 2.35 in European Americans) and rheumatoid arthritis (OR = 1.65 in Koreans).
|
28135245 |
2017 |
|
rs1376314937
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified <i>HIF1A Pro582Ser T</i> allele and <i>C</i>/<i>T</i> genotype as well as <i>AKNA -1372C>A</i> polymorphism A/A genotype as genetic factors associated with pSS.
|
28484714 |
2017 |
|
rs17266594
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results indicated that the SNPs (rs2736340, rs13277113) of the FAM167A-BLK region, but not the BANK1 SNPs (rs4522865, rs17266594, and rs10516487), were associated with the development of pSS in Han Chinese.
|
23899688 |
2013 |
|
rs2004640
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study is the first to demonstrate a significant association between primary SS and the IRF5 rs2004640 T allele.
|
18050197 |
2007 |
|
rs201802880
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We show that the p.Arg90His substitution, which is reported to cause reduced reactive oxygen species (ROS) production, predisposes to SLE (odds ratio (OR) = 3.47 in Asians (P<sub>meta</sub> = 3.1 × 10<sup>-104</sup>), OR = 2.61 in European Americans, OR = 2.02 in African Americans) and other autoimmune diseases, including primary Sjögren's syndrome (OR = 2.45 in Chinese, OR = 2.35 in European Americans) and rheumatoid arthritis (OR = 1.65 in Koreans).
|
28135245 |
2017 |