Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
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0.080 | GeneticVariation | BEFREE | Folate intake, serum homocysteine and methylenetetrahydrofolate reductase (MTHFR) C677T genotype are not associated with oral cancer risk in Puerto Rico. | 11925474 | 2002 |
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0.080 | GeneticVariation | BEFREE | Pooled results indicated that neither C677T</span> nor A1298C polymorphism was associated with oral cancer susceptibility. | 28138253 | 2017 |
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0.080 | GeneticVariation | BEFREE | The goals of this study were to evaluate the association of three genotypic polymorphism (MTHFR C677T, MTHFR A1298C and CBS 844ins68) and oral cancer risk in southeastern Brazilians and evaluate the interactions between polymorphisms and clinical histopathological parameters. | 26749456 | 2016 |
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0.080 | GeneticVariation | BEFREE | Here we observed MTHFR C677T to influence oral cancer susceptibility, while A1298C polymorphism associated with patient prognosis. | 20923444 | 2011 |
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0.080 | GeneticVariation | BEFREE | Those patients with MTHFR C677T CT and TT genotypes also had a lower risk of oral cancer metastasis. | 21737671 | 2011 |
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0.080 | GeneticVariation | BEFREE | Among these 14 variants, 9 variants were reported to be significantly associated with the risk of oral cancer (CYP1A1-MspI, CYP2E1-RsaI/PstI, MTHFR-C677T, p73-G4C14-to-A4T14, XRCC1-Arg194Trp, CYP1A1-Ile462Val, GSTM1-±, and NAT2 slow vs rapid). | 24102947 | 2014 |
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0.080 | GeneticVariation | BEFREE | Interaction between the MTHFR C677T polymorphism and alcohol--impact on oral cancer risk and multiple DNA methylation of tumor-related genes. | 20940365 | 2011 |
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0.080 | GeneticVariation | BEFREE | These results suggest that MTHFR C677T polymorphism may play a role in oral cancer carcinogenesis in Asian population and heavy drinkers. | 24488626 | 2014 |