|
rs1043679457
|
|
G |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs1057516264
|
|
TC |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs10761482
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We evaluated the effects of ANK3 rs10761482 genetic variation on diagnosis, and of the genotype-by-diagnosis interaction on the brain structure and the degree of age-related brain atrophy on magnetic resonance imaging data evaluated by voxel-based morphometry.
|
27488254 |
2016 |
|
rs1133174
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The most common haplotype (H1), comprising rs4935774-T, rs2298813-G, and rs1133174-G alleles (T/G/G) was associated with whole brain atrophy in both males and females (p=0.012 & p=0.013; respectively).
|
24938503 |
2014 |
|
rs1193124736
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the presence of the APP transgene, D257A mice also exhibited significant brain atrophy with apparent cortical thinning but no frank neuron loss.
|
24885175 |
2014 |
|
rs12273363
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Specifically, we examined nine BDNF single-nucleotide polymorphisms (SNPs; rs908867, rs11030094, rs6265, rs10501087, rs1157659, rs1491850, rs11030107, rs7127507 and rs12273363) previously associated with brain atrophy or memory deficits in mTBI.
|
28755387 |
2018 |
|
rs139632595
|
|
C |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs146539065
|
|
T |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs1554901898
|
|
G |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs1554902217
|
|
G |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs1555642784
|
|
TC |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs1555706928
|
|
A |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs1990622
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Neither TMEM106B (rs1990622_T), KCNMB2 (rs9637454_A), nor any of the non-risk alleles were associated with brain atrophy.
|
27003218 |
2016 |
|
rs2298813
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The most common haplotype (H1), comprising rs4935774-T, rs2298813-G, and rs1133174-G alleles (T/G/G) was associated with whole brain atrophy in both males and females (p=0.012 & p=0.013; respectively).
|
24938503 |
2014 |
|
rs28936415
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs363050
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Recent results showed that a reduction of SNAP-25 is associated with dementia, and that the rs363050 SNAP-25 polymorphism correlates with cognitive decline and brain atrophy, as well as with the outcome of multistructured rehabilitation in AD patients.
|
30914946 |
2019 |
|
rs405509
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among ε4/ε4 individuals, AD risk increased substantially in a dose-dependent manner with the number of <i>APOE</i> promoter SNP rs405509 <i>T</i> alleles in EastAs <i>(TT</i>: OR (odds ratio) = 27.02, <i>p</i> = 8.80 × 10<sup>-94</sup>; <i>GT</i>: OR = 15.87, <i>p</i> = 2.62 × 10<sup>-9</sup>) and EuroAs (<i>TT</i>: OR = 18.13, <i>p</i> = 2.69 × 10<sup>-108</sup>; <i>GT</i>: OR = 12.63, <i>p</i> = 3.44 × 10<sup>-64</sup>), and rs405509-<i>T</i> homozygotes had a younger onset and more severe cortical atrophy than those with <i>G</i>-allele.
|
31426376 |
2019 |
|
rs4935774
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The most common haplotype (H1), comprising rs4935774-T, rs2298813-G, and rs1133174-G alleles (T/G/G) was associated with whole brain atrophy in both males and females (p=0.012 & p=0.013; respectively).
|
24938503 |
2014 |
|
rs6265
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The BDNF Val66Met polymorphism is associated with cognitive impairment and brain atrophy among the non-demented elderly, APOEɛ4 non-carriers and A + subgroup, implying the potential of the Val66Met polymorphism as an important genetic factor for AD-related neurodegeneration.
|
30775992 |
2019 |
|
rs63750231
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Neuropathologically, PS1 E280A cases show pronounced brain atrophy, severe amyloid-β pathology, distinct hyperphosphorylated tau-related pathology, and cerebellar damage.
|
22766738 |
2012 |
|
rs63750231
|
|
|
0.020 |
GeneticVariation |
BEFREE |
To investigate whether a similar pattern of cortical atrophy is present in presymptomatic presenilin 1 E280A mutation carriers an average of 6 years before clinical symptom onset.
|
23134660 |
2013 |
|
rs63751273
|
|
|
0.010 |
GeneticVariation |
BEFREE |
P301L is the tau mutation most frequently observed in patients with frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17) and this mouse model recapitulates the progressive development of glial and neurofibrillary tangles, and associated cerebral atrophy observed in patients.
|
29568692 |
2018 |
|
rs672601366
|
|
G |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs704180
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, both rs704180 and rs73069071 risk genotypes were associated with widespread brain atrophy visualized by MRI (Alzheimer's Disease Neuroimaging Initiative data; n = 1239).
|
27815632 |
2016 |
|
rs7127507
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Specifically, we examined nine BDNF single-nucleotide polymorphisms (SNPs; rs908867, rs11030094, rs6265, rs10501087, rs1157659, rs1491850, rs11030107, rs7127507 and rs12273363) previously associated with brain atrophy or memory deficits in mTBI.
|
28755387 |
2018 |