The rs3787016 polymorphism, in polymerase II polypeptide E (POLR2E), was previously identified as being associated with the risk for prostate cancer, esophageal cancer, breast cancer, papillary thyroid carcinoma and liver cancer, suggesting that rs3787016 may server as a common genetic factor to affect individual susceptibility to cancer.
We here explored the association between POLR2E rs3787016 and risk of papillary thyroid carcinoma (PTC) in a Chinese population, which was followed by a meta-analysis of POLR2E rs3787016 and cancer risk in Chinese population.