rs2230199
|
|
|
0.900 |
GeneticVariation |
BEFREE |
No interaction was found between rs2230199 and smoking or other AMD loci.
|
19234341 |
2009 |
rs2230199
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The variant C3-rs2230199 showed no relation with AMD progression.
|
19797206 |
2010 |
rs2230199
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In contrast, the C3 variants rs2230199 and rs1047286 were not associated with exudative AMD in the studied subjects.
|
19850835 |
2010 |
rs2230199
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The G allele of the C3 IVS2 rs2250656, but not other tested C3 SNPs of rs2230205, rs10411506, rs2230199, rs339392, and rs163913, was significantly associated with a reduced risk for AMD in the Chinese population (OR 0.605, 95% CI 0.39-0.93, p = 0.023), even after adjusting for age, gender, smoking status, CFH rs1061170, CFB rs4151667, and CFB rs641153 allele status (OR 0.58, 95% CI 0.35-0.96, p = 0.033).
|
19899988 |
2009 |
rs2230199
|
|
C |
0.900 |
GeneticVariation |
GWASDB |
Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration.
|
20385819 |
2010 |
rs2230199
|
|
C |
0.900 |
GeneticVariation |
GWASCAT |
Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration.
|
20385819 |
2010 |
rs2230199
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC).
|
20385826 |
2010 |
rs2230199
|
|
|
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC).
|
20385826 |
2010 |
rs2230199
|
|
C |
0.900 |
GeneticVariation |
GWASDB |
Genome-wide association identifies SKIV2L and MYRIP as protective factors for age-related macular degeneration.
|
20861866 |
2010 |
rs2230199
|
|
C |
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide association identifies SKIV2L and MYRIP as protective factors for age-related macular degeneration.
|
20861866 |
2010 |
rs2230199
|
|
|
0.900 |
GeneticVariation |
BEFREE |
For rs2230199, patients with CG and GG genotypes were 1.44 (95% confidence interval (CI): 1.33, 1.56) and 1.88 (95% CI: 1.59, 2.23) times more likely to have AMD than patients with the CC genotype.
|
21576320 |
2011 |
rs2230199
|
|
C |
0.900 |
GeneticVariation |
GWASDB |
Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration.
|
21665990 |
2011 |
rs2230199
|
|
C |
0.900 |
GeneticVariation |
GWASCAT |
Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration.
|
21665990 |
2011 |
rs2230199
|
|
|
0.900 |
GeneticVariation |
BEFREE |
However, the risk allele is absent or rare (<1%) in Japanese and Chinese populations, and the association of R102G with AMD has not been reported in Asian populations.
|
22174912 |
2011 |
rs2230199
|
|
C |
0.900 |
GeneticVariation |
GWASDB |
Heritability and genome-wide association study to assess genetic differences between advanced age-related macular degeneration subtypes.
|
22705344 |
2012 |
rs2230199
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Genotyping was performed for the Y402H variant of CFH, for the L9H, R32Q, and K565E variants of CFB, the E318D variant of C2, the A69S variant of ARMS2, and the R102G variant of C3 in 159 Mexican mestizo patients at advanced stages of AMD, i.e., CARMS (Clinical Age-Related Maculopathy Staging System) grade 4 or 5.
|
23112567 |
2012 |
rs2230199
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Seven new loci associated with age-related macular degeneration.
|
23455636 |
2013 |
rs2230199
|
|
C |
0.900 |
GeneticVariation |
GWASCAT |
Seven new loci associated with age-related macular degeneration.
|
23455636 |
2013 |
rs2230199
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Seventeen single nucleotide polymorphisms (SNPs) in known AMD risk-associated genes including CFH (rs800292, rs3766404, rs1061170, rs2274700 and rs393955), HTRA1 (rs11200638), CFHR1-5 (rs10922153, rs16840639, rs6667243, and rs1853883), LOC387715/ARMS2 (rs3793917 and rs10490924), C3 (rs2230199 and rs1047286), C2 (rs547154), CFB (rs641153) and F13B (rs6003) were examined.
|
23582991 |
2013 |
rs2230199
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The risk alleles in C3 (rs1047286, odds ratio [OR]=2.48, 95% confidence interval [CI]=1.64-3.75, p=1.59E-05; rs2230199, OR=2.15, 95% CI=1.48-3.13, p=6.28E-05) and in ARMS2 (rs10490924, OR=3.09, 95% CI=2.48-3.86, p=5.42E-23) were strongly associated with risk of AMD.
|
24453474 |
2014 |
rs2230199
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The frequency of the rs2230199 G allele (minor allele) was significantly higher in patients with AMD in comparison with controls (0.34 vs 0.22, p = 0.0031) and similar to the frequency of other reported populations.
|
24519512 |
2014 |
rs2230199
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Higher C3d/C3 ratios were found for current smoker (p = 0.002), higher age (p = 1.56 × 10(-7)), AMD phenotype (p = 1.15 × 10(-11)) and the two SNPs in the C3 gene rs6795735 (p = 0.04) and rs2230199 (p = 0.04).
|
24675670 |
2014 |
rs2230199
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Significantly positive associations were found for the rs2230199 C/G SNP and AMD in the Caucasian population, as well as for the rs1047286 C/T SNP.
|
25688879 |
2015 |
rs2230199
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The associations of IL-8 rs4073 A→T, CFH rs1061170 T→C, ARMS2 rs10490924 G→T and C3 rs2230199 C→G SNPs with the presence of AMD and with the age of onset of exudative AMD were analysed.
|
26154559 |
2015 |
rs2230199
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In conclusion, our meta-analysis provides evidence that the rs2230199 polymorphism contributes to the development of AMD.
|
26505407 |
2015 |