In Bangladesh, the SPINK1 N34S mutation increases the risk of several forms of pancreatic disease, including fibrocalculous pancreatic diabetes, tropical calcific pancreatitis, and non-insulin-dependent diabetes mellitus.
Clear excess transmission of SPINK1N34S to the probands with FCPD</span> in 69 Bangladeshi families was observed (P<.0001; 20 transmissions and 2 nontransmissions).