Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs10419226
rs10419226
CRTC1
A 0.800 GeneticVariation GWASCAT A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus. 24121790

2013
dbSNP: rs10419226
rs10419226
CRTC1
A 0.800 GeneticVariation GWASDB A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus. 24121790

2013
dbSNP: rs11789015
rs11789015
BARX1
A 0.800 GeneticVariation GWASDB A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus. 24121790

2013
dbSNP: rs11789015
rs11789015
BARX1
A 0.800 GeneticVariation GWASCAT A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus. 24121790

2013
dbSNP: rs2342002
rs2342002 		T 0.800 GeneticVariation GWASDB A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus. 24121790

2013
dbSNP: rs2342002
rs2342002 		T 0.800 GeneticVariation GWASCAT A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus. 24121790

2013
dbSNP: rs2687201
rs2687201 		T 0.800 GeneticVariation GWASDB A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus. 24121790

2013
dbSNP: rs2687201
rs2687201 		T 0.800 GeneticVariation GWASCAT A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus. 24121790

2013
dbSNP: rs3784262
rs3784262
ALDH1A2
A 0.710 GeneticVariation GWASCAT A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus. 24121790

2013
dbSNP: rs2178146
rs2178146 		A 0.700 GeneticVariation GWASCAT A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus. 24121790

2013
dbSNP: rs4800353
rs4800353 		T 0.700 GeneticVariation GWASCAT A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus. 24121790

2013
dbSNP: rs7632500
rs7632500
LOC107986152
C 0.700 GeneticVariation GWASCAT A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus. 24121790

2013
dbSNP: rs1263178238
rs1263178238
VSIG10L
0.010 GeneticVariation BEFREE A multiplex, multigenerational family with 14 members affected (3 members with esophageal adenocarcinoma and 11 with Barrett esophagus) was identified, and whole-exome sequencing identified a germline mutation (S631G) at a highly conserved serine residue in the uncharacterized gene VSIG10L that segregated in affected members. 27467440

2016
dbSNP: rs25487
rs25487
XRCC1
0.020 GeneticVariation BEFREE Although no significant relationships were found for the XRCC1 Arg399Gln polymorphism alone, this polymorphism did modify the relationship between XPD Lys751Gln and EA risk; when both polymorphisms were evaluated together, adding the number of variant alleles of the two polymorphisms resulted in a significant trend (trend test, P = 0.008); compared with individuals with no variant alleles (n = 88), the adjusted ORs of developing EA are 1.49 (95% CI: 0.88-2.59), 1.69 (95% CI: 0.98-2.96) and 2.58 (95% CI: 1.31-5.06) for one (n = 195), two (n = 166) and three or four variant alleles (n = 70), respectively. 17264068

2007
dbSNP: rs11615
rs11615
ERCC1
0.010 GeneticVariation BEFREE Analysis of ERCC1 (rs11615) gene polymorphisms reveals a significant correlation with response and survival in patients with adenocarcinoma of the esophagus treated with a neoadjuvant radiochemotherapy. 21956434

2012
dbSNP: rs1042522
rs1042522
TP53
0.030 GeneticVariation BEFREE Association of MDM2 T309G and p53 Arg72Pro polymorphisms and gastroesophageal reflux disease with survival in esophageal adenocarcinoma. 23735059

2013
dbSNP: rs1131691014
rs1131691014
TP53
0.030 GeneticVariation BEFREE Association of MDM2 T309G and p53 Arg72Pro polymorphisms and gastroesophageal reflux disease with survival in esophageal adenocarcinoma. 23735059

2013
dbSNP: rs878854066
rs878854066
TP53
0.030 GeneticVariation BEFREE Association of MDM2 T309G and p53 Arg72Pro polymorphisms and gastroesophageal reflux disease with survival in esophageal adenocarcinoma. 23735059

2013
dbSNP: rs1353702185
rs1353702185
MDM2
0.020 GeneticVariation BEFREE Association of MDM2 T309G and p53 Arg72Pro polymorphisms and gastroesophageal reflux disease with survival in esophageal adenocarcinoma. 23735059

2013
dbSNP: rs1217691063
rs1217691063
MTHFR
0.010 GeneticVariation BEFREE Association of methylenetetrahydrofolate reductase C677T-A1298C polymorphisms with risk for esophageal adenocarcinoma, Barrett's esophagus, and reflux esophagitis. 21951971

2012
dbSNP: rs397507444
rs397507444
MTHFR
0.010 GeneticVariation BEFREE Association of methylenetetrahydrofolate reductase C677T-A1298C polymorphisms with risk for esophageal adenocarcinoma, Barrett's esophagus, and reflux esophagitis. 21951971

2012
dbSNP: rs13429103
rs13429103
LOC107985847
0.710 GeneticVariation BEFREE Ever smoking was associated with an almost 12-fold increase in risk of EA among individuals with rs13429103-AA genotype (odds ratio=11.82; 95% CI, 4.03-34.67). 29551738

2018
dbSNP: rs13429103
rs13429103
LOC107985847
A 0.710 GeneticVariation GWASCAT Ever smoking was associated with an almost 12-fold increase in risk of EA among individuals with rs13429103-AA genotype (odds ratio=11.82; 95% CI, 4.03-34.67). 29551738

2018
dbSNP: rs3794405
rs3794405
FLT1
0.010 GeneticVariation BEFREE FLT1 rs3794405 is significantly associated with OS in esophageal adenocarcinoma, whereby each variant allele confers a 45-60% increased risk of mortality. 26014353

2015
dbSNP: rs11901649
rs11901649
APOB
0.700 GeneticVariation GWASCAT Gastroesophageal reflux GWAS identifies risk loci that also associate with subsequent severe esophageal diseases. 31527586

2019