|
rs1555461176
|
|
AT |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs587776416
|
|
C |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs80358451
|
|
|
0.700 |
GeneticVariation |
UNIPROT |
|
|
|
|
rs199769221
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A relevant contribution of the Arg117His-mutation to pathogenesis of pancreatic cancer might be possible, since also asymptomatic individuals have been reported to carry this mutation and individuals with only mild symptoms may be undiagnosed as hp.
|
11062709 |
2000 |
|
rs17107315
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The N34S mutation of SPINK1 appears not to be a distinct genetic risk factor in patients with sporadic pancreatic cancer.
|
12649567 |
2003 |
|
rs113488022
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The BRAF V599E mutation was not found to be a major mutation in pancreatic cancers that had no K-ras codon 12 mutation.
|
12969789 |
2003 |
|
rs121913377
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The BRAF V599E mutation was not found to be a major mutation in pancreatic cancers that had no K-ras codon 12 mutation.
|
12969789 |
2003 |
|
rs17107315
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The frequencies of the promotor polymorphisms of IL10-627A, IL10-1117A, TNF-238A and TNF-308A in patients with alcoholic chronic pancreatitis, idiopathic pancreatitis, SPINK1-N34S-associated chronic pancreatitis and pancreatic cancer did not differ significantly from the control group.
|
14560157 |
2003 |
|
rs1223231582
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The frequencies of the promotor polymorphisms of IL10-627A, IL10-1117A, TNF-238A and TNF-308A in patients with alcoholic chronic pancreatitis, idiopathic pancreatitis, SPINK1-N34S-associated chronic pancreatitis and pancreatic cancer did not differ significantly from the control group.
|
14560157 |
2003 |
|
rs104894094
|
|
|
0.010 |
GeneticVariation |
BEFREE |
As compared with the general population, the risk of pancreatic cancer (PC) was increased 9.4-fold [95% confidence interval (CI) 2.7-33.4] and 2.2-fold (95% CI 0.8-5.7) in G101W-positive and -negative MF, respectively, while mean ages at onset were 61 and 77 years, respectively.
|
14679123 |
2004 |
|
rs121913529
|
|
|
0.050 |
GeneticVariation |
BEFREE |
We find that physiological levels of Kras(G12D) induce ductal lesions that recapitulate the full spectrum of human pancreatic intraepithelial neoplasias (PanINs), putative precursors to invasive pancreatic cancer.
|
14706336 |
2003 |
|
rs762846821
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Using the whole-cell recording mode of the patch-clamp technique, functional ion channels were electrophysiologically characterized in PANC-1 (K-ras G12D (+/-), p53 R273C, Deltap16), BxPC-3 (smad4-, p53 Y220C, Deltap16), and MiaPaCa-2 [transforming growth factor-beta receptor type II defect, K-ras G12C(-/-), p53 R248W, Deltap16] human pancreatic cancer cell lines.
|
14978241 |
2004 |
|
rs121912651
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Using the whole-cell recording mode of the patch-clamp technique, functional ion channels were electrophysiologically characterized in PANC-1 (K-ras G12D (+/-), p53 R273C, Deltap16), BxPC-3 (smad4-, p53 Y220C, Deltap16), and MiaPaCa-2 [transforming growth factor-beta receptor type II defect, K-ras G12C(-/-), p53 R248W, Deltap16] human pancreatic cancer cell lines.
|
14978241 |
2004 |
|
rs121912666
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Using the whole-cell recording mode of the patch-clamp technique, functional ion channels were electrophysiologically characterized in PANC-1 (K-ras G12D (+/-), p53 R273C, Deltap16), BxPC-3 (smad4-, p53 Y220C, Deltap16), and MiaPaCa-2 [transforming growth factor-beta receptor type II defect, K-ras G12C(-/-), p53 R248W, Deltap16] human pancreatic cancer cell lines.
|
14978241 |
2004 |
|
rs121913343
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Using the whole-cell recording mode of the patch-clamp technique, functional ion channels were electrophysiologically characterized in PANC-1 (K-ras G12D (+/-), p53 R273C, Deltap16), BxPC-3 (smad4-, p53 Y220C, Deltap16), and MiaPaCa-2 [transforming growth factor-beta receptor type II defect, K-ras G12C(-/-), p53 R248W, Deltap16] human pancreatic cancer cell lines.
|
14978241 |
2004 |
|
rs17107315
|
|
|
0.040 |
GeneticVariation |
BEFREE |
To our knowledge, this is the first reported case of chronic pancreatitis accompanied by pancreatic cancer in a patient with the SPINK1 N34S mutation.
|
15084977 |
2004 |
|
rs1223231582
|
|
|
0.020 |
GeneticVariation |
BEFREE |
To our knowledge, this is the first reported case of chronic pancreatitis accompanied by pancreatic cancer in a patient with the SPINK1 N34S mutation.
|
15084977 |
2004 |
|
rs397507851
|
|
C |
0.700 |
CausalMutation |
CLINVAR |
Nonsense-mediated mRNA decay: terminating erroneous gene expression.
|
15145354 |
2004 |
|
rs80358683
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
Nonsense-mediated mRNA decay: terminating erroneous gene expression.
|
15145354 |
2004 |
|
rs80359584
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
Nonsense-mediated mRNA decay: terminating erroneous gene expression.
|
15145354 |
2004 |
|
rs111966833
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The N34S and P55S mutations were determined by PCR amplification followed by solid-phase minisequencing in 116 patients with CP and in 188 with pancreatic cancer.
|
15764155 |
2005 |
|
rs397507444
|
|
|
0.050 |
GeneticVariation |
BEFREE |
We found that the C667T (but not the A1298C) polymorphism had a significant main effect on the risk of pancreatic cancer.
|
15941958 |
2005 |
|
rs486907
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In familial pancreatic cancer no association between Arg462Gln genotypes and pancreatic cancer risk was evident.
|
15981205 |
2005 |
|
rs74315364
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The Glu265X mutation was identified in one (2.8%) familial and one (1.3%) sporadic pancreatic cancer case, but not in any of the controls.
|
15981205 |
2005 |
|
rs1217691063
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Joint effect between MTHFR C677T polymorphism and smoking or drinking increased risk of pancreatic cancer in a super-multiplicative manner.
|
16234002 |
2005 |