|
rs1555461176
|
|
AT |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs587776416
|
|
C |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs80358451
|
|
|
0.700 |
GeneticVariation |
UNIPROT |
|
|
|
|
rs13181
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The present meta-analysis showed significant associations between deoxyribonucleic acid (DNA) repair gene (X-ray repair cross-complementing group 1 (XRCC1) Arg399GIn and Arg194Trp, excision repair cross complementation 1 (ERCC1) rs11615 and rs3212986, ERCC2 rs13181) polymorphisms and PC risk.
|
31393355 |
2019 |
|
rs13181
|
|
|
0.060 |
GeneticVariation |
BEFREE |
In addition, haplotype analysis revealed that haplotype AGG, which comprised rs13181, rs3916874 and rs238415, was associated with a 1.401-fold increase in pancreatic cancer risk (p < 0.05).
|
29260835 |
2019 |
|
rs1799782
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The present meta-analysis showed significant associations between deoxyribonucleic acid (DNA) repair gene (X-ray repair cross-complementing group 1 (XRCC1) Arg399GIn and Arg194Trp, excision repair cross complementation 1 (ERCC1) rs11615 and rs3212986, ERCC2 rs13181) polymorphisms and PC risk.
|
31393355 |
2019 |
|
rs13181
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Association between ERCC2 Lys751Gln polymorphism and the risk of pancreatic cancer, especially among Asians: evidence from a meta-analysis.
|
28223548 |
2017 |
|
rs13181
|
|
|
0.060 |
GeneticVariation |
BEFREE |
However, no significant difference was found between the ERCC2 rs13181 polymorphism and the risk of pancreatic cancer in the codominant, dominant, and recessive models.
|
27051038 |
2016 |
|
rs1799782
|
|
|
0.060 |
GeneticVariation |
BEFREE |
This study examined the main and interactive effect of 9 single-nucleotide polymorphisms (SNPs) (Arg194Trp, Arg280His, Arg399Gln, c.1254C>T, c.1517G>C, c.1471G>A, C310T, 539del542, and T1915C) of XRCC1 in contribution to pancreatic cancer (PC).
|
26418909 |
2016 |
|
rs1799782
|
|
|
0.060 |
GeneticVariation |
BEFREE |
In conclusion, we found that XRCC1 Arg399Gln genetic variations are associated with pancreatic cancer development, whereas the XRCC1 Arg280His and Arg194Trp polymorphisms did not affect pancreatic cancer risk.
|
27323136 |
2016 |
|
rs1799782
|
|
|
0.060 |
GeneticVariation |
BEFREE |
In the subgroup analysis based on ethnicity, there was no statistically significant association between XRCC1 rs1799782 genetic polymorphism and pancreatic cancer risk in Asians/Caucasians under all genetic models (all P values > 0.05).
|
24435745 |
2014 |
|
rs13181
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The increasing evidence of XPD-Lys751Gln impact on the outcome of gemcitabine-cisplatin-based polychemotherapy leads to plan prospective studies to validate the role of this polymorphism as a new tool for optimization of the currently available treatments in pancreatic cancer.
|
23390054 |
2013 |
|
rs13181
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The XPD Asp312Asn and Lys751Gln polymorphisms, corresponding haplotype, and pancreatic cancer risk.
|
16458430 |
2007 |
|
rs1799782
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Yet only one polymorphism, XRCC1 Arg194Trp, appears to be involved in smoking-related cancers and in early onset pancreatic cancer.
|
17397816 |
2007 |
|
rs1799782
|
|
|
0.060 |
GeneticVariation |
BEFREE |
We investigated the association between polymorphisms of MGMT (Leu(84)Phe and Ile(143)Val), APE1 (Asp(148)Glu), and XRCC1 (Arg(194)Trp and Arg(399)Gln) and risk of pancreatic cancer in a case-control study.
|
16844323 |
2006 |
|
rs1217691063
|
|
|
0.050 |
GeneticVariation |
BEFREE |
MTHFR gene C677T rather than A1298C polymorphism may be associated with PC.
|
31701291 |
2020 |
|
rs397507444
|
|
|
0.050 |
GeneticVariation |
BEFREE |
MTHFR gene C677T rather than A1298C polymorphism may be associated with PC.
|
31701291 |
2020 |
|
rs121913529
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Importantly, FGTI-2734 inhibited the growth of xenografts derived from four patients with pancreatic cancer with mutant KRAS (2 G12D and 2 G12V) tumors.
|
31227505 |
2019 |
|
rs121913529
|
|
|
0.050 |
GeneticVariation |
BEFREE |
KRAS G12D point mutation plays an important role in the incidence of non-small-cell lung cancer (NSCLC) as well as colorectal cancer, pancreatic cancer and breast cancer.
|
30876538 |
2019 |
|
rs121913529
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The dominant oncogenic mutations of KRAS are single amino acid substitutions at codon 12, in particular G12D and G12V present in 60% to 70% of pancreatic cancers and 20% to 30% of colorectal cancers.
|
26701267 |
2016 |
|
rs1217691063
|
|
|
0.050 |
GeneticVariation |
BEFREE |
We performed a meta-analysis of all relevant case-control studies that examined the association between MTHFR C677T polymorphism and pancreatic cancer risk.
|
23098468 |
2012 |
|
rs397507444
|
|
|
0.050 |
GeneticVariation |
BEFREE |
This meta-analysis indicated that MTHFR polymorphisms (C667T and A1298C) are not associated with pancreatic cancer risk.
|
23167392 |
2012 |
|
rs397507444
|
|
|
0.050 |
GeneticVariation |
BEFREE |
This meta-analysis indicated that MTHFR polymorphisms (C667T and A1298C) were not associated with pancreatic cancer risk.
|
22901202 |
2012 |
|
rs1217691063
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The risk for PC was higher in individuals with MTHFR C677T or TT polymorphisms and a smoking habit (OR = 2.52, 95% CI = 1.05-6.09, P = 0.04).
|
21441790 |
2011 |
|
rs121913529
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Oncogene-directed increased expression of Nrf2 is a new mechanism for the activation of the Nrf2 antioxidant program, and is evident in primary cells and tissues of mice expressing K-Ras(G12D) and B-Raf(V619E), and in human pancreatic cancer.
|
21734707 |
2011 |