SNP309 T alleles were associated with a significantly decreased prostate cancer risk among Pro72Arg Pro </span>alleles carriers (OR=0.79, 95% CI, 0.64-0.98).
Our study provided evidence that the P53 intron 6 G>A and R72P G>C polymorphisms were associated with a higher risk of prostate cancer in a Northern Indian population.
Although we did not find a significant relationship between the frequency of the Arg/Pro + Pro/Pro genotype of p53 Arg72Pro and susceptibility in PC, there was a combined effect of CXCL12 GA + AA genotype and the p53 72Arg/Pro + Pro/Pro genotype on the frequency of PC.