Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
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0.100 | GeneticVariation | BEFREE | Based on these results, the XRCC1-Arg399Gln polymorphism might be a risk factor for PCa and it could be considered as a prognostic and predictive biomarker for susceptible men. | 30160806 | 2018 |
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0.100 | GeneticVariation | BEFREE | Overall, the results of this meta-analysis show that the XRCC1-Arg399Gln polymorphism may be associated with an increased risk for prostate cancer under the homozygote model and the recessive model. | 25927275 | 2015 |
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0.100 | GeneticVariation | BEFREE | In summary, we suggest that XRCC1 Arg399Gln might be significantly associated with development of Pca. | 25262700 | 2015 |
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0.100 | GeneticVariation | BEFREE | We examined the association between PC risk with nonsynonymous SNPs (nsSNPs) in 5 genes involved in 3 DNA-repair pathways: (1) base excision repair (BER): hOGG1 C1245G (Ser326Cys) and XRCC1 G28152A (Arg399Gln); (2) nucleotide excision repair (NER): XPD G23591A (Asp312Asn); (3) homologous recombination repair: RAD51 G135C (in 5' untranslated region) and XRCC3 C18067T (Thr241Met). | 19914098 | 2012 |
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0.100 | GeneticVariation | BEFREE | In this meta-analysis, we found that both Arg399Gln and Arg194Trp polymorphisms were not related to overall PCa risk. | 21647176 | 2011 |
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0.100 | GeneticVariation | BEFREE | However, our results also suggested that XRCC1 Arg399Gln polymorphism was not significantly associated with pr</span>ostate cancer in white men. | 19428062 | 2009 |
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0.100 | GeneticVariation | BEFREE | Among the three polymorphisms, we found that the XRCC1 Arg399Gln variant allele was associated with increased PCa risk (adjusted odd ratio [OR]: 1.67, 95% confident interval [CI]: 1.11-2.51), but the XRCC1 Arg194Trp variant allele had a 38% reduction in risk of PCa (adjusted OR: 0.62, 95% CI: 0.41-0.93). | 17486273 | 2007 |
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0.100 | GeneticVariation | BEFREE | Haplotype analysis of XRCC1 Arg194Trp (C/T) and Arg399Gln (G/A) revealed that the frequency of the T-A haplotype was significantly higher in PC patients. | 17196815 | 2007 |
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0.100 | GeneticVariation | BEFREE | We found that the XRCC1-Arg399Gln AA and the MGMT-Leu84Phe CT+TT genotypes were associated with an increased risk of prostate cancer [odds ratio (OR), 2.18; 95% confidence interval (CI), 0.99-4.81 and OR, 1.99; 95% CI, 1.19-3.34, respectively]. | 16030105 | 2005 |
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0.100 | GeneticVariation | BEFREE | To determine whether the XRCC1 (codon Arg399Gln) and XPD (codon Asp312Asn and codon Lys751Gln) polymorphisms are associated with prostate cancer susceptibility, we genotyped these polymorphisms in a primarily Caucasian sample of 506 sibships (n = 1,117) ascertained through a brother with prostate cancer. | 14744728 | 2004 |