rs2735839
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Higher levels of PSA in the presence of KLK3 polymorphism in patients with PC indicated that rs2735839 polymorphism could be a risk factor for increased levels of PSA.
|
31017705 |
2019 |
rs2735839
|
|
|
0.800 |
GeneticVariation |
BEFREE |
No association was observed between the polymorphism A>G of rs2735839 and risk of PCa.
|
30413614 |
2018 |
rs2735839
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In summary, rs752822 and rs2735839 may assist in risk-stratifying GS 7 patients and predict prostate cancer reclassification.
|
27515962 |
2016 |
rs2735839
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Our results provide further support that a PC-risk SNP rs2735839 near the KLK3 gene on chromosome 19q13 may be associated with aggressive and high-grade PC.
|
25715684 |
2015 |
rs2735839
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We confirmed the association of the rs2735839 with high-aggressive prostate cancer (GS ≥8).
|
25274378 |
2014 |
rs2735839
|
|
|
0.800 |
GeneticVariation |
BEFREE |
When comparing prostate cancer cases with low PSA controls, alleles at genetic markers rs1512268, rs445114, rs10788160, rs11199874, rs17632542, rs266849, and rs2735839 were associated with an increased risk of prostate cancer, but the effect-estimates were attenuated to the null when using high PSA controls (Pheterogeneity in effect-estimates < 0.04).
|
24753544 |
2014 |
rs2735839
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Four GWAS replication SNPs (rs2660753, rs13254738, rs10090154, rs2735839) and seven flanking SNPs were associated with CaP aggressiveness (P < 0.05) in three genomic regions: One at 3p12 (EA), seven at 8q24 (5 AA, 2 EA), and three at 19q13 at the kallilkrein-related peptidase 3 (KLK3) locus (two AA, one AA and EA).
|
22549899 |
2013 |
rs2735839
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We did not observe a strong association with the KLK3 variant, reported in previous studies to confer risk for prostate cancer (rs2735839; P = 0.20) but did observe three highly correlated SNPs (rs17632542, rs62113212 and rs62113214) associated with prostate cancer [P = 3.41 × 10(-4), per-allele trend odds ratio (OR) = 0.77, 95% CI = 0.67-0.89].
|
21318478 |
2011 |
rs2735839
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Two SNPs, rs2735839 at chromosome 19q13 and rs7679673 at 4q24, were associated with prostate cancer-specific survival (P = 7 × 10(-4) and 0.014, respectively).
|
21367958 |
2011 |
rs2735839
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The rs61752561 in KLK3 and rs2735839 in the KLK2-KLK3 intergenic region were strongly associated with prostate cancer-specific survival, and rs10486567 in the 7JAZF1 gene were associated with biochemical recurrence.
|
20460480 |
2010 |
rs2735839
|
|
|
0.800 |
GeneticVariation |
BEFREE |
For the two SNPs that had significant differences between more and less aggressive disease rs2735839 in KLK3 (P = 8.4 x 10(-7)) and rs10993994 in MSMB (P = 0.046), the alleles that are associated with increased risk for PCa were more frequent in patients with less aggressive disease.
|
19434657 |
2009 |
rs2735839
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The reported risk allele (G) for single nucleotide polymorphism rs2735839 in the KLK3 gene at 19q13 was more frequent in less aggressive prostate cancer patients (0.89) than in more aggressive prostate cancer patients (0.86; nominal P = 0.03) or in controls (0.86; nominal P = 0.04).
|
18794092 |
2008 |