Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
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0.090 | GeneticVariation | BEFREE | The AA genotype and the A allele of rs4680 (COMT) appeared to be inversely associated with the risk of prostate cancer in adjusted models for both Afro-Caribbean and native African men. | 27074016 | 2016 |
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0.090 | GeneticVariation | BEFREE | We suggest that bladder cancer but not prostate cancer and kidney cancer could be significantly associated with the Val158Met polymorphism. | 27055785 | 2016 |
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0.090 | GeneticVariation | BEFREE | Collectively, the results of the present study suggest that significant associations o</span>f COMT Val158Met polymorphisms with prostate cancer were observed (for additive model: OR = 1.068, 95 % CI = 1.002-1.138, P (heterogeneity) = 0.363, P = 0.043; for dominant model: OR = 1.266, 95 % CI = 1.057-1.517, P (heterogeneity) = 0.000, P = 0.011; for recessive model: OR = 1.050, 95 % CI = 0.961-1.146, P (heterogeneity) = 0.558, P = 0.279; and Val allele versus Met allele OR = 0.932, 95 % CI = 0.894-0.971, P (heterogeneity) = 0.272, P = 0.001). | 23096092 | 2013 |
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0.090 | GeneticVariation | BEFREE | There is no association between the COMT Val158Met polymorphism and PCa. | 23116175 | 2013 |
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0.090 | GeneticVariation | BEFREE | This meta-analysis suggests that COMT Val158Met polymorphism might not be a risk factor for PCa risk. | 23257985 | 2013 |
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0.090 | GeneticVariation | BEFREE | Our results suggested that the Val158Met polymorphism of COMT was not associated with the risk of sporadic or latent prostate cancer in Japanese men. | 17760745 | 2007 |
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0.090 | GeneticVariation | BEFREE | To investigate potential non-receptor-mediated estrogen effects, we evaluated the association between COMT Val158Met and hOGG1 Ser326Cys polymorphisms and prostate cancer in a family-based case-control study (439 prostate cancer cases, 479 brother controls). | 16569655 | 2006 |
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0.090 | GeneticVariation | BEFREE | A total of 11 htSNPs (including COMT Val(158)Met) were selected based on the resequencing and dense genotyping approach of the Breast and Prostate Cancer Cohort Consortium. htSNPs were genotyped in a population-based, case-control study in Poland (1,995 cases and 2,296 controls). | 17018638 | 2006 |
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0.090 | GeneticVariation | BEFREE | The Val158Met polymorphism of COMT is associated with the PSA-progression-free rate of EMP-treated patients in prostate cancer. | 16126332 | 2005 |