Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1420106
rs1420106
IL18RAP
0.010 GeneticVariation BEFREE Hence, this study was performed to understand the role of 2 IL18RAP (rs1420106 and rs917997) polymorphisms and IL18RAP plasma levels in lumbar disc degeneration (LDD) in Indian population. 31147177

2019
dbSNP: rs731236
rs731236
VDR
0.010 GeneticVariation BEFREE TaqI (rs731236) polymorphism was associated with a predisposition to LDD. 31127184

2019
dbSNP: rs7975232
rs7975232
VDR
0.010 GeneticVariation BEFREE TaqMan SNP Genotyping Assay was utilized to probe VDR gene polymorphisms including the FokI (rs2228570), ApaI (rs7975232) and TaqI (rs731236) in 454 patients with LDD and 485 controls. 31127184

2019
dbSNP: rs917997
rs917997 		0.010 GeneticVariation BEFREE There was a significant association among females in CT genotype of rs917997 in LDD (p = 0.041). 31147177

2019
dbSNP: rs12077871
rs12077871
COL9A2
0.010 GeneticVariation BEFREE The meta-analysis of 10 case-control studies, including 2102 LDD cases and 2507 controls, indicated that COL9A2 gene (rs12077871, rs12722877, rs7533552) and COL9A3 gene (rs61734651) polymorphisms were not associated with LDD (rs12077871: T vs. C, OR = 1.85, 95% CI = 0.87-3.91, P = 0.11; rs12722877: G vs. C, OR = 0.83, 95% CI = 0.69-1.01, P = 0.06; rs7533552: G vs. A, OR = 1.11, 95% CI = 0.98-1.25, P = 0.09; rs61734651: T vs. C, OR = 1.57, 95% CI = 0.51-4.84, P = 0.43). 29506578

2018
dbSNP: rs1254394380
rs1254394380
COL11A1
0.010 GeneticVariation BEFREE Results suggest that COL11A1 4603C/T gene polymorphism is associated with an increased risk of CDD, but not LDD, in Japanese collegiate wrestlers. 28944648

2018
dbSNP: rs12722877
rs12722877
COL9A2
0.010 GeneticVariation BEFREE rs12077871, rs12722877, and rs7533552 variants in COL9A2 and rs61734651 variant in COL9A3 were not significantly associated with a predisposition to LDD. 29506578

2018
dbSNP: rs2073711
rs2073711
CILP
0.010 GeneticVariation BEFREE We conclude that the CILP gene polymorphism (rs2073711) is associated with a lower risk of LDD, the MMP3 (rs591058) gene polymorphism is associated with LDD among women, and the TT genotype confers a lower risk of LDD. 30288688

2018
dbSNP: rs591058
rs591058
MMP3
0.010 GeneticVariation BEFREE We conclude that the CILP gene polymorphism (rs2073711) is associated with a lower risk of LDD, the MMP3 (rs591058) gene polymorphism is associated with LDD among women, and the TT genotype confers a lower risk of LDD. 30288688

2018
dbSNP: rs61734651
rs61734651
COL9A3
0.010 GeneticVariation BEFREE rs12077871, rs12722877, and rs7533552 variants in COL9A2 and rs61734651 variant in COL9A3 were not significantly associated with a predisposition to LDD. 29506578

2018
dbSNP: rs7041
rs7041
GC
0.010 GeneticVariation BEFREE The minor allele of GC rs7041 was associated with a decreased risk of LDD (OR = 0.69; 95% CI 0.44-0.82, P = .001). 29316495

2018
dbSNP: rs1304037
rs1304037
IL1A
0.010 GeneticVariation BEFREE The rs2856836, rs1304037, rs17561 and rs1800587 variants of the IL1A gene were associated with the severity of LDD and Modic changes. 28081267

2017
dbSNP: rs1337185
rs1337185
COL11A1
0.010 GeneticVariation BEFREE The SNPs rs1337185 in <i>COL11A1</i> and rs162509 in <i>ADAMTS5</i> are associated with susceptibility to LDD. 28583914

2017
dbSNP: rs162509
rs162509
ADAMTS5 ; MIR4759
0.010 GeneticVariation BEFREE The SNPs rs1337185 in <i>COL11A1</i> and rs162509 in <i>ADAMTS5</i> are associated with susceptibility to LDD. 28583914

2017
dbSNP: rs17561
rs17561
IL1A
0.010 GeneticVariation BEFREE The rs2856836, rs1304037, rs17561 and rs1800587 variants of the IL1A gene were associated with the severity of LDD and Modic changes. 28081267

2017
dbSNP: rs1800587
rs1800587
IL1A
0.010 GeneticVariation BEFREE The rs2856836, rs1304037, rs17561 and rs1800587 variants of the IL1A gene were associated with the severity of LDD and Modic changes. 28081267

2017
dbSNP: rs226794
rs226794
ADAMTS5
0.010 GeneticVariation BEFREE The rs41270041 variant of the ADAMTS4 gene and the rs226794 variant of the ADAMTS5 gene were associated with severity of LDD while the rs34884997 variant of the ADAMTS4 gene, the rs55933916 variant of the ADAMTS5 gene and the rs9862 variant of the TIMP3 gene were associated with severity of Modic changes. 28081267

2017
dbSNP: rs2856836
rs2856836
IL1A
0.010 GeneticVariation BEFREE The rs2856836, rs1304037, rs17561 and rs1800587 variants of the IL1A gene were associated with the severity of LDD and Modic changes. 28081267

2017
dbSNP: rs34884997
rs34884997
ADAMTS4
0.010 GeneticVariation BEFREE The rs41270041 variant of the ADAMTS4 gene and the rs226794 variant of the ADAMTS5 gene were associated with severity of LDD while the rs34884997 variant of the ADAMTS4 gene, the rs55933916 variant of the ADAMTS5 gene and the rs9862 variant of the TIMP3 gene were associated with severity of Modic changes. 28081267

2017
dbSNP: rs41270041
rs41270041
ADAMTS4
0.010 GeneticVariation BEFREE The rs41270041 variant of the ADAMTS4 gene and the rs226794 variant of the ADAMTS5 gene were associated with severity of LDD while the rs34884997 variant of the ADAMTS4 gene, the rs55933916 variant of the ADAMTS5 gene and the rs9862 variant of the TIMP3 gene were associated with severity of Modic changes. 28081267

2017
dbSNP: rs20575
rs20575
TNFRSF10A
0.010 GeneticVariation BEFREE The C626G polymorphism of DR4 may be associated with the risk and severity of LDD in the Chinese Han population. 23050498

2012
dbSNP: rs4871857
rs4871857
TNFRSF10A
0.010 GeneticVariation BEFREE The present study aimed to determine whether the C626G polymorphism (rs4871857) of the DR4 gene is associated with the risk and severity of LDD in the Chinese Han population. 23050498

2012
dbSNP: rs2228570
rs2228570
VDR
0.020 GeneticVariation BEFREE TaqMan SNP Genotyping Assay was utilized to probe VDR gene polymorphisms including the FokI (rs2228570), ApaI (rs7975232) and TaqI (rs731236) in 454 patients with LDD and 485 controls. 31127184

2019
dbSNP: rs143383
rs143383
GDF5
0.020 GeneticVariation BEFREE In conclusion, CC mutant type at rs143383 in <i>GDF5</i> gene has a strong association with the incidence of LDD, and a high prevalence risk, but it has no evident correlation with pathological grades. 30186416

2018
dbSNP: rs2228570
rs2228570
VDR
0.020 GeneticVariation BEFREE Two single-nucleotide polymorphisms, VDR rs2228570 (FokI) and GC rs7041, were genotyped in 180 patients with LDD and 230 healthy individuals. 29316495

2018