rs11136000
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We also tested for epistatic interaction between these variants and APOE ε4 as well as with the previously replicated LOAD GWAS genes (CLU: rs11136000, CR1: rs3818361, and PICALM: rs3851179).
|
21321396 |
2011 |
rs11136000
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Recently, two large, and independent genome wide association studies of late-onset Alzheimer's disease (AD) established association with the same rs11136000 variation in the clusterin (CLU) gene.
|
20739100 |
2011 |
rs11136000
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The most significant single-nucleotide polymorphisms in CLU (rs11136000), CR1 (rs3818361), and PICALM (rs3851179) were tested for allelic association with LOAD.
|
20554627 |
2010 |
rs11136000
|
|
|
0.100 |
GeneticVariation |
BEFREE |
CLU-rs11136000-G associated with worse baseline memory and incident MCI/LOAD.
|
25189118 |
2015 |
rs11136000
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Single nucleotide polymorphisms at the LOAD risk loci CLU (rs11136000), CR1 (rs6656401, rs3818361), and PICALM (rs3851179) were genotyped and tested for association with Logical Memory immediate recall, Logical Memory delayed recall, Logical Memory percent retention, Visual Reproduction immediate recall, Visual Reproduction delayed recall, and Visual Reproduction percent retention scores from the Wechsler Memory Scale-Revised using multivariable linear regression analysis, adjusting for age at exam, sex, education, and apolipoprotein E ε4 dosage.
|
23643458 |
2014 |
rs11136000
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In order to evaluate association with these genome-wide association study-identified genes and to isolate the variants contributing to the pathogenesis of LOAD, we genotyped the top single nucleotide polymorphisms (SNPs), rs11136000 (CLU), rs3818361 (CR1), and rs3851179 (PICALM), and sequenced the entire coding regions of these genes in our cohort of 342 LOAD patients and 277 control subjects.
|
22402018 |
2012 |
rs11136000
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The C allele at the rs11136000 locus in the clusterin (CLU) gene is the third strongest known genetic risk factor for late-onset Alzheimer's disease (LOAD).
|
24806679 |
2014 |
rs11136000
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We validated the risk for LOAD with BIN1 (rs744373), CR1 (rs6656401), and ABCA7 (rs376465), as well as the protective association for MS4A6A (rs610932) and CLU (rs11136000) variants.
|
29504051 |
2018 |
rs11136000
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found by multivariate logistic regression analysis, that single nucleotide polymorphisms (SNPs) in CR1 (rs6656401 adjusted allelic p = 0.035; adjusted genotypic p = 0.043) and CLU (rs2279590 adjusted allelic p = 0.035; adjusted genotypic p = 0.006; rs11136000 adjusted allelic p = 0.038; adjusted genotypic p = 0.009) were significantly different between LOAD patients and nondemented controls.
|
22015308 |
2012 |
rs11136000
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Several genome-wide association studies have found that the rs11136000 polymorphism of the C allele (CLU-C) is associated with the risk for developing late-onset Alzheimer's disease (LOAD).
|
27396407 |
2016 |
rs11136000
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay was performed on genotype rs11136000 and APOEε4 in 127 patients with late-onset Alzheimer's disease and 143 control individuals.
|
22296908 |
2011 |
rs11136000
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There was evidence of association for recently-reported LOAD risk loci, including BIN1 (rs7561528, p = 0.009 with, and p = 0.03 without, APOE adjustment) and CLU (rs11136000, p = 0.023 with, and p = 0.008 without, APOE adjustment), with weaker support for CR1.
|
21379329 |
2011 |
rs3851179
|
|
|
0.090 |
GeneticVariation |
BEFREE |
For PICALM, LOAD association was found only in the APOE ε4 (-) subgroup (rs3851179 adjusted allelic p = 0.028; adjusted genotypic p = 0.013).
|
22015308 |
2012 |
rs3851179
|
|
|
0.090 |
GeneticVariation |
BEFREE |
A case-control study was conducted in 362 individuals (181 LOADs and 181 controls) to determine the association of single-nucleotide polymorphisms in APOE (e2, e3, and e4), TOMM40 (rs2075650), CR1 (rs665640), PVRL2 (rs6859), SORL1 (rs11218304), PICALM (rs3851179), and GWA_14q32.13 (rs11622883) with LOAD in a sample from Colombia.
|
27023435 |
2017 |
rs3851179
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The most significant single-nucleotide polymorphisms in CLU (rs11136000), CR1 (rs3818361), and PICALM (rs3851179) were tested for allelic association with LOAD.
|
20554627 |
2010 |
rs3851179
|
|
|
0.090 |
GeneticVariation |
BEFREE |
PICALM-rs3851179-G had an unexpected protective effect on incident MCI/LOAD.
|
25189118 |
2015 |
rs3851179
|
|
|
0.090 |
GeneticVariation |
BEFREE |
In order to evaluate association with these genome-wide association study-identified genes and to isolate the variants contributing to the pathogenesis of LOAD, we genotyped the top single nucleotide polymorphisms (SNPs), rs11136000 (CLU), rs3818361 (CR1), and rs3851179 (PICALM), and sequenced the entire coding regions of these genes in our cohort of 342 LOAD patients and 277 control subjects.
|
22402018 |
2012 |
rs3851179
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Single nucleotide polymorphisms at the LOAD risk loci CLU (rs11136000), CR1 (rs6656401, rs3818361), and PICALM (rs3851179) were genotyped and tested for association with Logical Memory immediate recall, Logical Memory delayed recall, Logical Memory percent retention, Visual Reproduction immediate recall, Visual Reproduction delayed recall, and Visual Reproduction percent retention scores from the Wechsler Memory Scale-Revised using multivariable linear regression analysis, adjusting for age at exam, sex, education, and apolipoprotein E ε4 dosage.
|
23643458 |
2014 |
rs3851179
|
|
|
0.090 |
GeneticVariation |
BEFREE |
We also tested for epistatic interaction between these variants and APOE ε4 as well as with the previously replicated LOAD GWAS genes (CLU: rs11136000, CR1: rs3818361, and PICALM: rs3851179).
|
21321396 |
2011 |
rs3851179
|
|
|
0.090 |
GeneticVariation |
BEFREE |
In addition, one variation, rs3851179, in the phosphatidylinositol binding clathrin assembly protein (PICALM) gene and one variation, rs6656401, in the complement component (3b/4b) receptor 1 (CR) gene were associated with AD.
|
20739100 |
2011 |
rs3851179
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The effects for all SNPs, except rs3851179, were consistent with those for LOAD risk.
|
24670887 |
2014 |
rs10524523
|
|
|
0.080 |
GeneticVariation |
BEFREE |
A variable poly-T length polymorphism at rs10524523, within intron 6 of the translocase of the outer mitochondrial membrane (TOMM40) gene, has been shown to influence age of onset in LOAD, with very long (VL) poly-T length associated with earlier disease onset, and short poly-T length associated with later onset.
|
21784354 |
2011 |
rs10524523
|
|
|
0.080 |
GeneticVariation |
BEFREE |
In two independent clinical cohorts, longer lengths of rs10524523 are associated with a higher risk for LOAD.
|
20029386 |
2010 |
rs10524523
|
|
|
0.080 |
GeneticVariation |
BEFREE |
We conclude that the poly-T repeat associations of rs10524523 in TOMM40 reflect the APOE ε4-dependent association in LOAD.
|
25500937 |
2014 |
rs10524523
|
|
|
0.080 |
GeneticVariation |
BEFREE |
We conclude that in the carriers of TOMM40-APOE haplotypes comprising E4 allele, the TOMM40 rs10524523 allele does not play substantial role in establishing LOAD risk.
|
22008263 |
2012 |