In conclusion, we have demonstrated that the rare TT genotype of the C677T polymorphism in the MTHFR gene is associated with increased risk of osteoporotic fractures in women and a weak predictor of lumbar spine BMD.
In the subgroup analysis by ethnicity, the results also showed no significant association between MTHFR C677T poly</span>morphism and susceptibility to osteoporotic fracture in postmenopausal women in both Caucasian and Asian populations.