| Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
|---|---|---|---|---|---|---|---|---|---|---|
|
0.070 | GeneticVariation | BEFREE | The association between the EPHX1 Tyr113His and His139Arg</span> polymorphisms and EC risk was pooled by odds ratios (ORs) together with their 95% confidence intervals (95%CIs). | 25714851 | 2015 |
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|
0.070 | GeneticVariation | BEFREE | However, no evidence was found for the association between the EPHX1 Hi</span>s139Arg polymorphism and esophageal cancer risk. | 24615030 | 2014 |
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|
0.070 | GeneticVariation | BEFREE | This meta-analysis suggests that the p.Tyr113His and p.His139Arg polymorphisms in EPHX1 may not be associated with EC development. | 24803829 | 2014 |
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|
0.070 | GeneticVariation | BEFREE | Meta-analysis of these seven studies for EPHX1 H</span>is139Arg polymorphism showed that EPHX1 His139Arg polymorphism was also not associated with esophageal cancer</span> risk under all genetic models. | 23681797 | 2013 |
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|
0.070 | GeneticVariation | BEFREE | No significant association was found in either the allele or genotype models for Tyr113His or His1</span>39Arg polymorphism with risk for esophageal cancer</span>. | 24222229 | 2013 |
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|
0.070 | GeneticVariation | BEFREE | A comprehensive systematic review and meta-analysis was performed of available studies on these two polymorphisms and cancer risk published up to November 2010, consisting of 84 studies (31144 cases and 42439 controls) for Tyr113His and 77 studies (28496 cases and 38506 controls) for His139Arg primarily focused on lung cancer, upper aerodigestive tract (UADT) cancers (including oral, pharynx, larynx and esophagus cancers), colorectal cancer or adenoma, bladder cancer and breast cancer. | 21445251 | 2011 |
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|
0.070 | GeneticVariation | BEFREE | EPHX1 exon 4 139His/Arg, and 139Arg/Arg genotypes were associated with a higher risk of esophageal cancer in a high-risk area of India. | 20659238 | 2010 |