rs1042522
|
|
|
0.080 |
GeneticVariation |
BEFREE |
We conducted a case-control study to examine whether two polymorphisms (i.e., rs4938723 in the promoter of pri-miR-34b/c and TP53 Arg72Pro) were linked to the carcinogenesis of cervical cancer among Chinese Han women.
|
26619844 |
2016 |
rs1042522
|
|
|
0.080 |
GeneticVariation |
BEFREE |
These findings suggest that under at least some conditions, the modulation of apoptosis by the R72P polymorphism does not affect the process of carcinogenesis.
|
20587514 |
2010 |
rs1042522
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Polymorphism of p53 gene codon72 arginine (Arg)/proline (Pro) (rs1042522) may influence the function of p53 protein and then affect the processing of carcinogenesis.
|
24326769 |
2014 |
rs1042522
|
|
|
0.080 |
GeneticVariation |
BEFREE |
So, as to find the association of p53Arg <sup>72</sup> Pro towards lung carcinogenesis and overall survival of North Indian lung cancer patients, single nucleotide polymorphic variant (rs1042522) was analyzed.
|
27614750 |
2016 |
rs1042522
|
|
|
0.080 |
GeneticVariation |
BEFREE |
In addition to TP53 gene mutations, a common polymorphism, Arg72Pro, has been involved in the carcinogenesis process.
|
18068527 |
2008 |
rs1042522
|
|
|
0.080 |
GeneticVariation |
BEFREE |
In case-only analysis, the homozygous p73 G4C14-to-A4T14 variant of p73 genotype was associated with the presence of the p53 exon 4 Arg72Pro allele (OR = 1.30, 95% CI, 1.02-1.64), which is suggestive of a biological interaction between the two genes in carcinogenesis.
|
21976716 |
2012 |
rs1042522
|
|
|
0.080 |
GeneticVariation |
BEFREE |
It is evident from our study that Arg72Pro SNP of TP53 gene is connected with higher susceptibility to thyroid cancer especially in young age group, female gender, non-smokers and patients with elevated TSH levels, hence, implicated in thyroid carcinogenesis.
|
25835179 |
2015 |
rs1042522
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Similar thus inconclusive results are observed in ovarian cancer, which may suggest that the rs1042522 does not influence ovarian carcinogenesis directly, but might be linked to another pathogenic alteration.
|
23192612 |
2013 |
rs1131691014
|
|
|
0.050 |
GeneticVariation |
BEFREE |
It is evident from our study that Arg72Pro SNP of TP53 gene is connected with higher susceptibility to thyroid cancer especially in young age group, female gender, non-smokers and patients with elevated TSH levels, hence, implicated in thyroid carcinogenesis.
|
25835179 |
2015 |
rs1131691014
|
|
|
0.050 |
GeneticVariation |
BEFREE |
In case-only analysis, the homozygous p73 G4C14-to-A4T14 variant of p73 genotype was associated with the presence of the p53 exon 4 Arg72Pro allele (OR = 1.30, 95% CI, 1.02-1.64), which is suggestive of a biological interaction between the two genes in carcinogenesis.
|
21976716 |
2012 |
rs1131691014
|
|
|
0.050 |
GeneticVariation |
BEFREE |
We conducted a case-control study to examine whether two polymorphisms (i.e., rs4938723 in the promoter of pri-miR-34b/c and TP53 Arg72Pro) were linked to the carcinogenesis of cervical cancer among Chinese Han women.
|
26619844 |
2016 |
rs1131691014
|
|
|
0.050 |
GeneticVariation |
BEFREE |
These findings suggest that under at least some conditions, the modulation of apoptosis by the R72P polymorphism does not affect the process of carcinogenesis.
|
20587514 |
2010 |
rs1131691014
|
|
|
0.050 |
GeneticVariation |
BEFREE |
In addition to TP53 gene mutations, a common polymorphism, Arg72Pro, has been involved in the carcinogenesis process.
|
18068527 |
2008 |
rs121912664
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The mechanisms of adrenal tumorigenesis remain poorly established; the R337H germline mutation in the p53 gene has previously been associated with ACTs in Brazilian children.
|
15952083 |
2005 |
rs121912664
|
|
|
0.050 |
GeneticVariation |
BEFREE |
In conclusion, the R337H mutation has significant predictive and prognostic value and is associated with tumorigenesis of the adrenal cortex.
|
26681051 |
2015 |
rs121912664
|
|
|
0.050 |
GeneticVariation |
BEFREE |
By modeling a <i>TP53</i> mutation in mice that has relatively weak cancer penetrance, this study provides <i>in vivo</i> evidence that the human R337H mutation can compromise p53 activity and promote tumorigenesis.<b>Significance:</b> A germline mutation in the oligomerization domain of p53 decreases its transactivation potential and renders mice susceptible to carcinogen-induced liver tumorigenesis.<i></i>.
|
30042151 |
2018 |
rs121912664
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Moreover, loss of heterozygocity with retention of the R337H allele was observed in a breast adenocarcinoma, supporting a role for this mutation in breast tumorigenesis.
|
16494995 |
2007 |
rs121912664
|
|
|
0.050 |
GeneticVariation |
BEFREE |
However, other tumor types, mainly breast cancer, have been observed in carriers of several unrelated kindreds, raising the possibility that the R337H mutation may also contribute to breast tumorigenesis in a genetic background-specific context.
|
19046423 |
2008 |
rs878854066
|
|
|
0.050 |
GeneticVariation |
BEFREE |
In case-only analysis, the homozygous p73 G4C14-to-A4T14 variant of p73 genotype was associated with the presence of the p53 exon 4 Arg72Pro allele (OR = 1.30, 95% CI, 1.02-1.64), which is suggestive of a biological interaction between the two genes in carcinogenesis.
|
21976716 |
2012 |
rs878854066
|
|
|
0.050 |
GeneticVariation |
BEFREE |
These findings suggest that under at least some conditions, the modulation of apoptosis by the R72P polymorphism does not affect the process of carcinogenesis.
|
20587514 |
2010 |
rs878854066
|
|
|
0.050 |
GeneticVariation |
BEFREE |
It is evident from our study that Arg72Pro SNP of TP53 gene is connected with higher susceptibility to thyroid cancer especially in young age group, female gender, non-smokers and patients with elevated TSH levels, hence, implicated in thyroid carcinogenesis.
|
25835179 |
2015 |
rs878854066
|
|
|
0.050 |
GeneticVariation |
BEFREE |
In addition to TP53 gene mutations, a common polymorphism, Arg72Pro, has been involved in the carcinogenesis process.
|
18068527 |
2008 |
rs878854066
|
|
|
0.050 |
GeneticVariation |
BEFREE |
We conducted a case-control study to examine whether two polymorphisms (i.e., rs4938723 in the promoter of pri-miR-34b/c and TP53 Arg72Pro) were linked to the carcinogenesis of cervical cancer among Chinese Han women.
|
26619844 |
2016 |
rs28934576
|
|
|
0.040 |
GeneticVariation |
BEFREE |
These results indicate that mutant TP53 G245C and R273H can lead to more aggressive phenotypes and enhance cancer cell malignancy, which further uncover TP53 function in carcinogenesis and might be useful in clinical diagnosis and therapy of TP53 mutant cancers.
|
30126368 |
2018 |
rs28934576
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Heterozygous p53(R270H/+)WAPCre mice (with mammary gland-specific expression of the p53.R270H mutation, equivalent to human R273H, at physiologic levels) develop mammary tumors at high frequency, indicating that the R270H mutation predisposes for mammary gland tumor development and acts in a dominant-negative manner in early stages of tumorigenesis.
|
16166291 |
2005 |