| Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
|---|---|---|---|---|---|---|---|---|---|---|
|
0.800 | GeneticVariation | BEFREE | There was a stronger association between the G84E variant and PC among men with no first-degree relative with PC (OR, 4.04; 95% CI, 1.12-14.51) compared to men with a family history of PC (OR, 1.49; 95% CI, 0.30-7.50; P = 0.36 for interaction). | 23129385 | 2013 |
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0.800 | GeneticVariation | BEFREE | These findings demonstrate that the HOXB13 G84E mutation is present in ~5 % of prostate cancer families, predominantly of European descent, and confirm its association with prostate cancer risk. | 23064873 | 2013 |
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|
0.800 | GeneticVariation | BEFREE | This study confirms the overall importance of the HOXB13 G84E mutation in prostate cancer susceptibility. | 23292082 | 2013 |
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|
0.800 | GeneticVariation | BEFREE | We identified 101 heterozygous carriers of G84E who underwent radical prostatectomy for prostate cancer between 1985 and 2011 and matched these men by race, age and tumor grade to 99 HOXB13 wild-type controls. | 28186998 | 2017 |
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|
0.800 | GeneticVariation | BEFREE | We performed a retrospective analysis of germline DNA samples from Ashkenazi Jewish men and a comparison group of non-Ashkenazi men treated for prostate cancer at our institution to determine the prevalence of HOXB13 G84E mutation in prostate cancer patients of Ashkenazi Jewish heritage, an ethnic group common to the New York City area. | 23475555 | 2013 |
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0.800 | GeneticVariation | BEFREE | While the HOXB13 G84E mutation may be rare, there may be a future role in genetic testing for this mutation after further studies of clinical utility in assessing prostate cancer risk. | 24310616 | 2014 |
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|
0.800 | GeneticVariation | BEFREE | While there was a trend toward an earlier age at diagnosis, overall the clinicopathologic features of PCa were not significantly different in G84E carriers and non-carriers. | 29181843 | 2018 |