Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
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0.070 | GeneticVariation | BEFREE | Nevertheless, in the subgroup analysis by ethnicity, we identified that <i>IL-6</i>-rs1800795 polymorphism was associated with an increased risk of PCa for Caucasian individuals in dominant model (MM + MW vs. WW: OR = 1.245, 95%CI = 1.176-1.318, <i>P</i> < 0.001). | 30854108 | 2019 |
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0.070 | GeneticVariation | BEFREE | The C allele of rs1800795 was associated with PCa r</span>isk in the assessed population (OR (95% CI) = 1.45 (1.06-1.98)). | 30345492 | 2019 |
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0.070 | GeneticVariation | BEFREE | The Role of Interleukin-6 Polymorphism (rs1800795) in Prostate Cancer Development and Progression. | 29848725 | 2018 |
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0.070 | GeneticVariation | BEFREE | Overall estimates revealed no significant relationship between IL-6 rs1800795 polymorphism and prostate cancer risk in total analysis, but a risk-increasing effect of the polymorphism was detected in African-American subgroup under CC versus GG and CC versus GG + GC contrasts (OR 3.43, 95% CI 1.01-11.71; OR 3.51, 95% CI 1.04-11.82) after subgroup analysis by ethnicity.IL-6 rs1800795 polymorphism may enhance the susceptibility to prostate cancer in African-American men. | 28296724 | 2017 |
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0.070 | GeneticVariation | BEFREE | We investigated the role of two functional polymorphisms, IL-6-174G>C (rs1800795) and IL-6-572C>G (rs1800796), in the development of prostate cancer. | 26535651 | 2015 |
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0.070 | GeneticVariation | BEFREE | Direct sequencing of the PCR amplicon from genomic DNA was used for genotyping rs1800795 in all subjects [age-matched controls (N = 140) and prostate cancer patients (N = 164)]. | 24446297 | 2014 |
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0.070 | GeneticVariation | BEFREE | SNPs at the CRP locus are not associated with PCa risk in this cohort, while the association between rs1800795 and PCa risk warrants further investigation. | 19267250 | 2009 |