|
rs121917864
|
|
|
0.010 |
GeneticVariation |
BEFREE |
TLR2 gene Arg677Trp, Arg753Gln, 196-174 del and TLR4 gene Asp299Gly, Thr399Ile polymorphism do not appear to have a role in the development of HT disease.
|
30924423 |
2020 |
|
rs3027452
|
|
|
0.010 |
GeneticVariation |
BEFREE |
MAOB rs3027452-A allele carriers were significantly over-represented among hypertensive (HT) patients (25.49%) in comparison to either the non-HT patients (10%, OR = 3.079 CI<sub>95</sub> [1.364-6.952], p = .005, Chi-square test) and the control population series of nonobese nor hypogonadic males (also 10%, p = .003 Chi-square test).
|
31743621 |
2020 |
|
rs5743708
|
|
|
0.010 |
GeneticVariation |
BEFREE |
TLR2 gene Arg677Trp, Arg753Gln, 196-174 del and TLR4 gene Asp299Gly, Thr399Ile polymorphism do not appear to have a role in the development of HT disease.
|
30924423 |
2020 |
|
rs10004195
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified that two SNPs, rs165501 (OR = 1.20, P = 0.0008, IRAK2) and rs10004195 (OR = 1.23, P = 0.0001, TLR10), were identified to be significantly associated with HD.
|
31073143 |
2019 |
|
rs1061501
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, a genetic effect of rs1061501 on regulating serum IFN-α production was observed in HT.
|
31494956 |
2019 |
|
rs11568820
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Another functional polymorphism of the <i>VDR</i> gene, rs11568820 (Cdx2), has been shown to influence the immune system, although it has not been studied for its association with autoimmune thyroiditis to date.
|
31531369 |
2019 |
|
rs12492609
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that the allele T of rs12492609 in <i>TMEM39A</i> was associated with AITD and Hashimoto's thyroiditis (HT) (<i>p</i> = 0.023; <i>p</i> = 0.028 respectively).
|
31553233 |
2019 |
|
rs12944194
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified three variants suggestively associated with HT: rs12944194 located 206 kb from SDK2 (P = 1.8 × 10<sup>-6</sup>), rs75201096 inside GNA14 (P = 2.41 × 10<sup>-5</sup>) and rs791903 inside IP6K3 (P = 3.16 × 10<sup>-5</sup>).
|
30284222 |
2019 |
|
rs13277113
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results showed reduced percentages of the G allele of rs13277113 of BLK in GD (P = 0.037, odds ratio [OR] = 0.78, 95% confidence interval [CI] = 0.62-0.99) and HT (P = 0.002, OR = 0.54, 95% CI = 0.36-0.81), compared to the controls.
|
30589937 |
2019 |
|
rs165501
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified that two SNPs, rs165501 (OR = 1.20, P = 0.0008, IRAK2) and rs10004195 (OR = 1.23, P = 0.0001, TLR10), were identified to be significantly associated with HD.
|
31073143 |
2019 |
|
rs2160322
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The MAGI2 gene polymorphism rs2160322 is associated with Graves' disease but not with Hashimoto's thyroiditis.
|
30535759 |
2019 |
|
rs2736340
|
|
|
0.010 |
GeneticVariation |
BEFREE |
At the same time, lower frequencies of the C allele of rs2736340 of BLK in GD (P = 0.025, OR = 0.76, 95% CI = 0.60-0.97) and HT (P = 0.003, OR = 0.53, 95% CI = 0.35-0.81) than the controls were also observed.
|
30589937 |
2019 |
|
rs327463
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CEP128 rs327463 was substantially related to GD under the allele model (OR = 1.31, 95%CI 1.08-1.59, P = 0.006) and the dominant model (OR = 1.37, 95%CI 1.09-1.72, P = 0.008), and it was related to HT under the recessive model (OR = 1.85, P = 0.031) and the homozygous model (OR = 1.91, P = 0.025).
|
30393005 |
2019 |
|
rs3761548
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype analysis revealed an increased frequency of rs3761548 "C"-rs3761549 "T" in HT and GD subjects, thereby associating it with disease predisposition (p = 0.03).
|
30771152 |
2019 |
|
rs3761549
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype analysis revealed an increased frequency of rs3761548 "C"-rs3761549 "T" in HT and GD subjects, thereby associating it with disease predisposition (p = 0.03).
|
30771152 |
2019 |
|
rs75201096
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified three variants suggestively associated with HT: rs12944194 located 206 kb from SDK2 (P = 1.8 × 10<sup>-6</sup>), rs75201096 inside GNA14 (P = 2.41 × 10<sup>-5</sup>) and rs791903 inside IP6K3 (P = 3.16 × 10<sup>-5</sup>).
|
30284222 |
2019 |
|
rs7629750
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Further, there was an obvious difference in the genotype distributions of rs12492609 and rs7629750 between HT patients with hypothyroidism and those without hypothyroidism (<i>p</i> = 0.034 and <i>p</i> = 0.023, respectively).
|
31553233 |
2019 |
|
rs791903
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified three variants suggestively associated with HT: rs12944194 located 206 kb from SDK2 (P = 1.8 × 10<sup>-6</sup>), rs75201096 inside GNA14 (P = 2.41 × 10<sup>-5</sup>) and rs791903 inside IP6K3 (P = 3.16 × 10<sup>-5</sup>).
|
30284222 |
2019 |
|
rs121434569
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We present a rare case of CASTLE, occurring in association with Hashimoto thyroiditis, with emphasis on cytological features and report for the first time the presence of a low level somatic mutation in EGFR (EGFR T790M mutation).
|
29115061 |
2018 |
|
rs1800469
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the present study, we attempted to investigate whether -509C/T SNP (rs1800469) in the promoter of TGFB1 is associated with the genetic susceptibility and clinical characteristics of Bulgarian patients with HT.
|
30070177 |
2018 |
|
rs225014
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the D2 rs225014 polymorphism, the TT genotype, which was correlated with higher D2 activity, was less frequent in AITD, especially in HD, than in control subjects (P = 0.0032 and 0.0002, respectively).
|
29648895 |
2018 |
|
rs2292779
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We genotyped AGO1 rs636832A/G, AGO2 rs7005286C/T, AGO2 rs11166985A/G and AGO2 rs2292779C/G polymorphisms in 184 Graves' disease (GD) patients, 195 Hashimoto's disease (HD) patients and 122 healthy volunteers using the polymerase chain reaction-restriction fragment length polymorphism method.
|
29256262 |
2018 |
|
rs2563298
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The study was aimed to determine whether four single nucleotide polymorphisms (rs2915863, rs2569190, rs2569192, and rs2563298) of CD14 are associated with AITDs and its subgroups of GD and HT.
|
30700980 |
2018 |
|
rs2569192
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The study was aimed to determine whether four single nucleotide polymorphisms (rs2915863, rs2569190, rs2569192, and rs2563298) of CD14 are associated with AITDs and its subgroups of GD and HT.
|
30700980 |
2018 |
|
rs4149570
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These data suggest that these five SNPs in the <i>TNFRSF1A</i> gene are not associated with AITD in the Chinese Han population, but rs4149570 shows a weak association with HT after adjusting for gender and age.
|
29401539 |
2018 |