rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
ADPRT Val762Ala and XRCC1 Arg194Trp polymorphisms and risk of gastric cancer in Sichuan of China.
|
22901183 |
2012 |
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, significant associations between Arg194Trp polymorphism and gastric cancer were found in Asian.
|
25335737 |
2014 |
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, the XRCC1 Arg399Gln and Arg280His polymorphisms were shown to have no influence on the development of gastric cancer.
|
27706710 |
2016 |
rs25489
|
|
|
0.060 |
GeneticVariation |
BEFREE |
However, the XRCC1 Arg399Gln and Arg280His polymorphisms were shown to have no influence on the development of gastric cancer.
|
27706710 |
2016 |
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, we did not find any association of polymorphism of XRCC1 Arg399Gln (OR = 1.56; 95% CI: 0.32-7.82) and XPD Lys751Gln (OR = 0.46; CI: 0.10-2.19) with GC risk in the study population.
|
30225185 |
2018 |
rs377566281
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition to tumour stage, which is an important prognostic factor affecting to the survival of stomach cancer patients, the genetic variant Gln339Arg in XRCC1 may non-significantly contribute to risk of stomach cancer death among Thai people.
|
26320504 |
2015 |
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, we suggest that the XRCC1 gene Arg194Trp polymorphism is associated with gastric cancer susceptibility in the Chinese population.
|
27706710 |
2016 |
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, XRCC1 Arg194Trp homozygous mutant genotype (Trp/Trp) was found to be associated with increased risk of GC.
|
21604176 |
2012 |
rs25489
|
|
|
0.060 |
GeneticVariation |
BEFREE |
In our association study between three amino acid substitution polymorphisms of XRCC1 (Arg194Trp, Arg280His, and Arg399Gln) and the risk of gastric cancer in the Korean population, none of the polymorphisms were associated with increased risk of gastric cancer.
|
12359351 |
2002 |
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In our association study between three amino acid substitution polymorphisms of XRCC1 (Arg194Trp, Arg280His, and Arg399Gln) and the risk of gastric cancer in the Korean population, none of the polymorphisms were associated with increased risk of gastric cancer.
|
12359351 |
2002 |
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In particular, individuals with the XRCC1 Arg194Trp variant genotype are at increased risk for GC below 60 years old.
|
23317230 |
2012 |
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
No association is found between the XRCC1 polymorphism Arg399Gln and gastric cancer risk.
|
19034980 |
2008 |
rs25489
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Our findings demonstrated that the genetic variant Arg280His in XRCC1 may contribute to cancer progression and that XRCC1 Arg194Trp variants may act as a favorable prognostic indicator of resected GC, particularly among the diffuse-type GC.
|
23425027 |
2013 |
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings demonstrated that the genetic variant Arg280His in XRCC1 may contribute to cancer progression and that XRCC1 Arg194Trp variants may act as a favorable prognostic indicator of resected GC, particularly among the diffuse-type GC.
|
23425027 |
2013 |
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings demonstrated that XRCC1 gene rs25487 polymorphism might play a leading role in pronounced susceptibility to gastric cancer in Han Chinese.
|
26590607 |
2016 |
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our meta-analysis indicates that genetic polymorphism of the XRCC1 Arg399Gln and Arg280His do not have an association with gastric cancer risk.
|
25335737 |
2014 |
rs25489
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Our meta-analysis indicates that genetic polymorphism of the XRCC1 Arg399Gln and Arg280His do not have an association with gastric cancer risk.
|
25335737 |
2014 |
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Polymorphic variants of base excision repair (APE1-D148E, XRCC1-R194W, XRCC1-R399Q and OGG1-S326C), nucleotide excision repair (XPC-PAT, XPA-23G>A, ERCC1-19007T>C and XPD-L751Q), recombination (XRCC3-T241M) and alkylation damage reversal (MGMT-L84F) were tested for their potential role in the development of GC by using logistic regression models.
|
20817763 |
2010 |
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Polymorphic variants of base excision repair (APE1-D148E, XRCC1-R194W, XRCC1-R399Q and OGG1-S326C), nucleotide excision repair (XPC-PAT, XPA-23G>A, ERCC1-19007T>C and XPD-L751Q), recombination (XRCC3-T241M) and alkylation damage reversal (MGMT-L84F) were tested for their potential role in the development of GC by using logistic regression models.
|
20817763 |
2010 |
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Arg399Gln SNP is not associated with the cardia type of gastric cancer.
|
21216841 |
2011 |
rs2293035
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The association analyses suggested that these two genetic variants were statistically associated with the increased risk of gastric cancer (for c.1254C>T, T versus C: odds ratio (OR) = 1.44, 95% confidence interval (CI) 1.17-1.77; for c.1779C>G, G versus C: OR = 1.51, 95% CI 1.22-1.86).
|
24779987 |
2014 |
rs148611340
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The association analyses suggested that these two genetic variants were statistically associated with the increased risk of gastric cancer (for c.1254C>T, T versus C: odds ratio (OR) = 1.44, 95% confidence interval (CI) 1.17-1.77; for c.1779C>G, G versus C: OR = 1.51, 95% CI 1.22-1.86).
|
24779987 |
2014 |
rs25489
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The authors performed a systematic review and meta-analysis of associations of the x-ray repair cross-complementing 1 gene (XRCC1) single nucleotide polymorphisms (SNPs) Arg194Trp, Arg280His, and Arg399Gln with gastric cancer risk, based on eligible studies retrieved from electronic databases for the period January 2000-December 2009.
|
21216841 |
2011 |
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The data suggest that the XRCC1 Arg399Gln polymorphism may be a prognostic biomarker of OS for platinum-based gastric cancer treatment.
|
24634242 |
2014 |
rs25489
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The results of the overall meta-analysis did not suggest any association between Arg280His/Arg399Gln polymorphisms and GC susceptibility for all genetic models.
|
21604176 |
2012 |