rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These results suggest that the MTHFR C677T and A1298C polymorphisms by themselves do not play an important role in the etiology of stomach cancer in the Korean population.
|
16158971 |
2005 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
C677T, A1298C and G1793A) and their haplotypes are associated with the risk of gastric cancer.
|
15643524 |
2005 |
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These results suggest that the MTHFR C677T and A1298C polymorphisms by themselves do not play an important role in the etiology of stomach cancer in the Korean population.
|
16158971 |
2005 |
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
C677T, A1298C and G1793A) and their haplotypes are associated with the risk of gastric cancer.
|
15643524 |
2005 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Recently, methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) mutations were discovered to be associated with childhood acute lymphoblastic leukemia (ALL), as well as colon cancer, lymphoma, esophageal and stomach cancer.
|
16886608 |
2006 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Methylenetetrahydrofolate reductase 677C>T polymorphism and gastric cancer susceptibility in Mexico.
|
16359859 |
2006 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To clarify the influence of MTHFR C677T and A1298C polymorphisms on ga</span>stric cancer (GC), a meta-analysis of eight case-control studies (1,584/2,785 cases/controls) was carried out.
|
16758123 |
2006 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We performed a case-control study to examine the relationship between MTHFR C677T gene polymorphism (MTHFR677C/T) and gastric cancer susceptibility in at-risk populations in central Italy.
|
16094648 |
2006 |
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To clarify the influence of MTHFR C677T and A1298C polymorphisms on gastric cancer (GC), a meta-analysis of eight case-control studies (1,584/2,785 cases/controls) was carried out.
|
16758123 |
2006 |
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Recently, methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) mutations were discovered to be associated with childhood acute lymphoblastic leukemia (ALL), as well as colon cancer, lymphoma, esophageal and stomach cancer.
|
16886608 |
2006 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found that a joint effect exits between the MTHFR C677T and A1298C polymorphism on the risk of gastric carcinoma.
|
18019157 |
2007 |
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
No obvious association between the MTHFR A1298C polymorphism and the risk of stomach cancer was observed in this study.
|
17438654 |
2007 |
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found that a joint effect exits between the MTHFR C677T and A1298C polymorphism on the risk of gastric carcinoma.
|
18019157 |
2007 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The authors performed a meta-analysis and individual data pooled analysis of case-control studies that examined the association between C677T and A1298C polymorphisms (the former being associated with low folate serum levels) and gastric cancer (meta-analyses: 16 studies, 2,727 cases and 4,640 controls for C677T and seven studies, 1,223 cases and 2,015 controls for A1298C; pooled analyses: nine studies, 1,540 cases and 2,577 controls for C677T and five studies, 1,146 cases and 1,549 controls for A1298C).
|
18162478 |
2008 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Assuming a very low prior probability of 0.000001, similar to a probability assumed for a randomly selected single-nucleotide polymorphism in a genome-wide association study, and statistical power to detect an OR of 1.5, 4 associations were considered noteworthy as denoted by an FPRP value <0.2: GSTM1 null and bladder cancer (OR, 1.5; 95% CI, 1.3-1.6; P = 1.9 x 10(-14)), NAT2 slow acetylator and bladder cancer (OR, 1.46; 95% CI, 1.26-1.68; P = 2.5 x 10(-7)), MTHFR C677T and gastric cancer (OR, 1.52; 95% CI, 1.31-1.77; P = 4.9 x 10(-8)), and GSTM1 null and acute leukemia (OR, 1.20; 95% CI, 1.14-1.25; P = 8.6 x 10(-15)).
|
18505952 |
2008 |
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The authors performed a meta-analysis and individual data pooled analysis of case-control studies that examined the association between C677T and A1298C polymorphisms (the former being associated with low folate serum levels) and gastric cancer (meta-analyses: 16 studies, 2,727 cases and 4,640 controls for C677T and seven studies, 1,223 cases and 2,015 controls for A1298C; pooled analyses: nine studies, 1,540 cases and 2,577 controls for C677T and five studies, 1,146 cases and 1,549 controls for A1298C).
|
18162478 |
2008 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The MTHFR C677T frequencies of CC, CT, and TT genotypes were 35.2%, 47.5%, and 17.3% among stomach cancer, 34%, 50.5%, and 15.5% in colorectal cancer, and 31.8%, 50.7%, and 17.5% in the controls, respectively.
|
20504332 |
2010 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The evidence from our meta-analysis supports that TT genotype of MTHFR C677T polymorphism contributes to susceptibility to gastric cancer, but no significant association was detected for CC genotype of MTHFR A1298C.
|
20470942 |
2010 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
MTHFR C677T polymorphism and differential methylation status in gastric cancer: an association with Helicobacter pylori infection.
|
20957490 |
2010 |
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric cancer: a meta-analysis.
|
20470942 |
2010 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, in meta-analyses odds ratio for MTHFR c.677C>T homozygotes versus noncarriers were 1.07 (95% CI: 1.01-1.12) for any cancer, 1.77 (1.17-2.68) for esophagus cancer, 1.40 (1.19-1.66) for gastric cancer and 0.85 (0.77-0.94) for colorectal cancer.
|
20473868 |
2011 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Decrease in gastric cancer susceptibility by MTHFR C677T polymorphism in Ardabil Province, Iran.
|
23934457 |
2013 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
MTHFR C677T polymorphism is a risk factor for GC, and the A1298C polymorphism may be a protective factor against GC in eastern populations.
|
25170232 |
2014 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Overall, the ORs under five contrast models indicated that the MTHFR C6</span>77T variant was positively associated with gastric cancer risk (ORT vs. C = 1.21, 95% CI 1.10–1.34, P(OR) < 0.001; OR(TT vs. CC) = 1.47, 95% CI 1.22–1.76, P(OR) < 0.001; OR(TC vs. CC) = 1.20, 95% CI 1.03-1.40, P(OR) = 0.022; OR(TT + TC vs. CC) = 1.27, 95% CI 1.10-1.47, P(OR) = 0.001; OR(TT vs. CC + TC) = 1.29, 95% CI 1.15-1.46, P(OR) < 0.001).
|
24122207 |
2014 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis supports an association between the MTHFR C677T polymorphism and increased risk of esophageal and stom</span>ach cancer, especially among Asians.
|
24744129 |
2014 |