rs2294008
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Our meta-analysis supports that the PSCA gene variant rs2294008 polymorphism might contribute to individual susceptibility to bladder cancer.
|
31008939 |
2019 |
rs2294008
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Cumulative evidence of an association was graded as strong for rs2294008 [odds ratio (OR) = 1.32, P = 5.1 × 10-33], rs2976392 (OR = 1.29, P = 1.8 × 10-8), rs9297976 (OR = 0.75, P = 1.4 × 10-7), rs2976391 (OR = 1.38, P = 6.1 × 10-5) and rs138377917 (OR = 0.53, P = 0.008) with gastric cancer, rs2294008 with bladder cancer (OR = 1.15, P = 8.0 × 10-19), gastritis (OR = 1.35, P = 1.2 × 10-5), duodenal ulcer (OR = 0.68, P = 2.4 × 10-57) and gastric ulcer (OR = 0.88, P = 1.7 × 10-7).
|
30407486 |
2019 |
rs2294008
|
|
|
0.800 |
GeneticVariation |
BEFREE |
For the PSCA rs2294008 polymorphism, when stratified by type of cancer, the results were significant especially in gastric cancer and bladder cancer.
|
28881685 |
2017 |
rs2294008
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Based on the statistical evidence, we can draw a conclusion that the rs2294008 polymorphism of PSCA gene is likely to play a role in cancer carcinogenesis, especially in gastric cancer and bladder cancer.
|
26308216 |
2015 |
rs2294008
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In conclusion, the results suggest that the PSCA rs2294008 (C>T) polymorphism is a risk factor for bladder cancer development.
|
25117309 |
2014 |
rs2294008
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Our study showed that the rs2294008 polymorphism in the PSCA gene is associated with the risk of bladder cancer in a Korean population, providing evidence that it may contribute to bladder carcinogenesis regardless of ethnicity.
|
25374226 |
2014 |
rs2294008
|
|
T |
0.800 |
GeneticVariation |
GWASCAT |
Genome-wide association study identifies multiple loci associated with bladder cancer risk.
|
24163127 |
2014 |
rs2294008
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Overall, seven of the 14 variants were significantly associated with bladder cancer risk (p = 9.763 × 10(-3) for rs9642880 at 8q24.21, p = 3.004 × 10(-3) for rs2294008 at 8q24.3, p = 0.012 for rs798766 at 4p16.3, p = 0.034 for rs1495741 at 8p22, p = 2.306 × 10(-4) for GSTM1, p = 8.507 × 10(-8) for rs17674580 at 18q12.3, p = 7.179 × 10(-4) for rs10936599 at 3q26.2) and the odds ratios (ORs) ranged from 1.13 to 1.65.
|
24740636 |
2014 |
rs2294008
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The study suggests that anti-PSCA immunotherapy might be beneficial for bladder cancer patients with high tumor PSCA expression, which is statistically significantly associated with the presence of CT and TT genotypes of a common genetic variant, rs2294008.
|
23266392 |
2013 |
rs2294008
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In conclusion, a joint effect of two PSCA SNPs, rs2294008 and rs2978974, suggests that both variants may be important for bladder cancer susceptibility, possibly through different mechanisms that influence the control of mRNA expression and interaction with regulatory factors.
|
22416122 |
2012 |
rs2294008
|
|
T |
0.800 |
GeneticVariation |
GWASCAT |
A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.
|
20972438 |
2010 |
rs2294008
|
|
|
0.800 |
GeneticVariation |
BEFREE |
These results indicated that the rs2294008 pol</span>ymorphism of PSCA gene may play a role in bladder cancer carcinogenesis and it could be served as a biomarker for genetic susceptibility to bladder cancer in Chinese populations.
|
20083643 |
2010 |
rs2294008
|
|
T |
0.800 |
GeneticVariation |
GWASCAT |
Our data identify rs2294008 as a new bladder cancer susceptibility locus.
|
19648920 |
2009 |
rs2294008
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Our data identify rs2294008 as a new bladder cancer susceptibility locus.
|
19648920 |
2009 |