Using the additive model, two tightly linked functional SNPs in ERCC6 were significantly associated with increased risk of NMSC: rs2228527 (odds ratio (OR) 1.57, 95% confidence interval (CI) 1.20-2.05) and rs2228529 (OR 1.57, 95% CI 1.20-2.05).
We found that the G allele of rs2228527 and the G allele of rs2228529 within <i>NER</i> gene, interaction between rs2228529 and current smoking were all associated with increased NMSC risk.