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rs1495741
|
|
|
0.030 |
GeneticVariation |
BEFREE |
tagSNP rs1495741 as a useful molecular marker to predict antituberculosis drug-induced hepatotoxicity.
|
27104815 |
2016 |
|
rs1495741
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The NAT2 tag SNP rs1495741 correlates with the susceptibility of antituberculosis drug-induced hepatotoxicity.
|
23407048 |
2013 |
|
rs1495741
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Two SNPs in NAT2 (rs1041983 and rs1495741) and NAT2 slow acetylators (SA) were significantly associated with INH-DILI (OR (95% CI) = 13.86 (4.30-44.70), 0.10 (0.03-0.33) and 9.98 (3.32-33.80), respectively).
|
29036176 |
2017 |
|
rs116561224
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We did not associate any specific drug classes with genetic polymorphisms, except for statin-associated DILI, which was associated with rs116561224 on chromosome 18 (OR, 5.4; 95% CI, 3.0-9.5; P = 7.1 × 10<sup>-9</sup>).
|
28043905 |
2017 |
|
rs4430924
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After correcting for weight and hepatoprotectant use, conditional logistic regression analysis showed that patients carrying the AA genotype of rs4430924 in</span> XPO1 were at higher risk of anti-TB drug-induced hepatotoxicity than those carrying the GG genotype based on the subgroup of probable cases (adjusted OR, 1.938; 95%CI, 1.035-3.628; P = .039), and marginally significant differences were also found under the recessive model (P = .048) and the additive model (P = .047).
|
30817003 |
2019 |
|
rs72631567
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We associated DILI with rs114577328 (a proxy for A*33:01 a HLA class I allele; odds ratio [OR], 2.7; 95% confidence interval [CI], 1.9-3.8; P = 2.4 × 10<sup>-8</sup>) and with rs72631567 on chromosome 2 (OR, 2.0; 95% CI, 1.6-2.5; P = 9.7 × 10<sup>-9</sup>).
|
28043905 |
2017 |
|
rs2287622
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A common variant (rs2287622; p.V444A) in the gene encoding BSEP has been associated with an increased risk of cholestatic DILI.
|
30608704 |
2019 |
|
rs2287622
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Patients carrying the C allele in the ABCB11 1331T>C polymorphism are at increased risk of developing hepatocellular type of DILI, when taking drugs containing a carbocyclic system with aromatic rings.
|
23701583 |
2013 |
|
rs138642043
|
|
|
0.010 |
GeneticVariation |
BEFREE |
On sequencing, ATP8B1 was normal in both patients although the younger was heterozygous for the c.2093G>A mutation in ABCB11, a polymorphism previously encountered in drug-induced liver injury.
|
23750872 |
2013 |
|
rs1214110864
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Four highly conserved nonsynonymous mutations were specific for drug-induced liver injury [ABCB11: D676Y (drug-induced cholestasis) and G855R (drug-induced cholestasis); ABCB4: I764L (drug-induced cholestasis) and L1082Q (drug-induced hepatocellular injury)].
|
17264802 |
2007 |
|
rs1966862
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study suggested rs1966862 (ARHGAP24) and the other SNPs to be predictive factors for drug-induced hepatotoxicity during the maintenance phase in pediatric patients with ALL or LBL.
|
20670164 |
2010 |
|
rs117806152
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Rs79280755 increased the risk of ATDILI significantly whether in additive (OR = 3.218, 95% CI: 1.686-6.139, PBonferroni correction = .003) or dominant model (PBonferroni correction = .003), as well as rs117806152 (Additive model: PBonferroni correction = .05; dominant model: PBonferroni correction = .03).
|
31689868 |
2019 |
|
rs231775
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A significant association was found between the rs231775 genotype and an early onset of DILI in the recipients.
|
23300559 |
2012 |
|
rs3087243
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We investigated the association of 5 CTLA4 single-nucleotide polymorphisms (SNPs) (rs733618 C/T, rs4553808 A/G, rs5742909 C/T, rs231775 A/G, and rs3087243 G/A) with drug-induced liver injury (DILI) in Chinese renal transplantation (RT) recipients.
|
23300559 |
2012 |
|
rs4553808
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We investigated the association of 5 CTLA4 single-nucleotide polymorphisms (SNPs) (rs733618 C/T, rs4553808 A/G, rs5742909 C/T, rs231775 A/G, and rs3087243 G/A) with drug-induced liver injury (DILI) in Chinese renal transplantation (RT) recipients.
|
23300559 |
2012 |
|
rs5742909
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We investigated the association of 5 CTLA4 single-nucleotide polymorphisms (SNPs) (rs733618 C/T, rs4553808 A/G, rs5742909 C/T, rs231775 A/G, and rs3087243 G/A) with drug-induced liver injury (DILI) in Chinese renal transplantation (RT) recipients.
|
23300559 |
2012 |
|
rs733618
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Five haplotypes were estimated for 4 SNPs (excluding rs733618); the frequency of haplotype ACGG was significantly higher in the DILI group (68.9%) than in the non-DILI group (61.1%) (p = 0.041).
|
23300559 |
2012 |
|
rs80292941
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings strongly suggest that <i>LINC00152</i> may promote TB progression and highlight rs80292941 single nucleotide polymorphism as a novel predisposition marker for antituberculosis drug-induced hepatotoxicity.
|
29383173 |
2017 |
|
rs1050450
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We have evaluated possible associations between the risk of developing DILI and common genetic variants of the manganese superoxide dismutase (SOD2 Val16Ala) and glutathione peroxidase (GPX1 Pro200Leu) genes, which are involved in mitochondrial oxidative stress management.
|
20578157 |
2010 |
|
rs114577328
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We associated DILI with rs114577328 (a proxy for A*33:01 a HLA class I allele; odds ratio [OR], 2.7; 95% confidence interval [CI], 1.9-3.8; P = 2.4 × 10<sup>-8</sup>) and with rs72631567 on chromosome 2 (OR, 2.0; 95% CI, 1.6-2.5; P = 9.7 × 10<sup>-9</sup>).
|
28043905 |
2017 |
|
rs9274407
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The strongest effect was with an HLA class II SNP (rs9274407, P=4.8×10(-14)), which correlated with rs3135388, a tag SNP of HLA-DRB1*1501-DQB1*0602 that was previously associated with AC-DILI.
|
21570397 |
2011 |
|
rs3135388
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The strongest effect was with an HLA class II SNP (rs9274407, P=4.8×10(-14)), which correlated with rs3135388, a tag SNP of HLA-DRB1*1501-DQB1*0602 that was previously associated with AC-DILI.
|
21570397 |
2011 |
|
rs1800796
|
|
|
0.010 |
GeneticVariation |
BEFREE |
rs1800796 of the IL6 gene is associated with increased risk for anti-tuberculosis drug-induced hepatotoxicity in Chinese Han children.
|
30029918 |
2018 |
|
rs1041983
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two SNPs in NAT2 (rs1041983 and rs1495741) and NAT2 slow acetylators (SA) were significantly associated with INH-DILI (OR (95% CI) = 13.86 (4.30-44.70), 0.10 (0.03-0.33) and 9.98 (3.32-33.80), respectively).
|
29036176 |
2017 |
|
rs17036170
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Limited contribution of common genetic variants to risk for liver injury due to a variety of drugs.
|
22968431 |
2012 |