| Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
|---|---|---|---|---|---|---|---|---|---|---|
|
0.780 | GeneticVariation | BEFREE | We conclude that PCLO SNP rs2522833 is associated with a gray matter volume reduction in the left temporal pole in drug-naive, first-episode patients with MDD carrying the C-allele. | 28556829 | 2017 |
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|
0.780 | GeneticVariation | BEFREE | Functional characterization of the PCLO p.Ser4814Ala variant associated with major depressive disorder reveals cellular but not behavioral differences. | 26045179 | 2015 |
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|
0.780 | GeneticVariation | BEFREE | Recent genome-wide association studies have pointed to single-nucleotide polymorphisms (SNPs) in genes encoding the neuronal calcium channel CaV1.2 (CACNA1C; rs1006737) and the presynaptic active zone protein Piccolo (PCLO; rs2522833) as risk factors for affective disorders, particularly major depression. | 24643163 | 2014 |
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|
0.780 | GeneticVariation | BEFREE | Although we did not take into account rare variants, we conclude that our results provide further support for the hypothesis that the non-synonymous coding SNP rs2522833 in the PCLO gene is indeed likely to be the causal variant in the GAIN-MDD cohort. | 24278217 | 2013 |
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|
0.780 | GeneticVariation | BEFREE | A genome-wide association study implicated the polymorphism rs2522833 in the piccolo (PCLO) gene--involved in monoaminergic neurotransmission--as a risk factor for MDD. | 22832909 | 2012 |
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|
0.780 | GeneticVariation | BEFREE | A recent genome-wide association study on Major Depressive Disorder (MDD) identified a specific association with a non-synonymous polymorphism (rs2522833) of a gene encoding the presynaptic protein piccolo (PCLO). | 22386049 | 2012 |
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|
0.780 | GeneticVariation | BEFREE | Recent genetic studies showed evidence for a role of the single-nucleotide polymorphism rs2522833 within the PCLO gene in the etiology of major depression, and rs2522833 has been shown to modulate hypothalamic pituitary adrenal (HPA) axis activity during antidepressant treatment. | 22832399 | 2011 |
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|
0.780 | GeneticVariation | BEFREE | PCLO rs2522833 modulates HPA system response to antidepressant treatment in major depressive disorder. | 20701824 | 2011 |
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0.780 | GeneticVariation | GWASDB | Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo. | 19065144 | 2009 |