A search of PubMed was conducted to investigate the association between DR4 C626G, A683Cand A1322G polymorphisms and cancer risk, using odds ratios (ORs) with 95% confidence intervals.
This SNP resulted in a non synonymous substitution of Glutamic acid to Alanine in position 228 (E228A), a change previously associated with susceptibility to different cancer types and risk of metastases, suggesting a lack of functionality of TRAILR-1.
In summary, this meta-analysis suggests that TRAIL-R1 C626G polymorphism is marginally associated with cancer susceptibility, and both TRAIL-R1 A1322G G allele and A683C C allele are associated with increased risk for cancer.