|
rs2075786
|
|
|
0.010 |
GeneticVariation |
BEFREE |
POT1 rs10244817, TERT rs2075786, and TERF2 rs251796 were significantly associated with lung cancer (p(trend)< or =0.05).
|
19285750 |
2009 |
|
rs2736098
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The TERT rs2735940 g.C > T and rs2736098 g.G > A, and TNKS1 rs6985140 g.A > G were significantly associated with the risk of lung cancer.
|
19773453 |
2009 |
|
rs2735940
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The TERT rs2735940 g.C > T and rs2736098 g.G > A, and TNKS1 rs6985140 g.A > G were significantly associated with the risk of lung cancer.
|
19773453 |
2009 |
|
rs2736100
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A statistically significant association between lung cancer risk and 5p15.33 genotypes was found: rs2736100 (odds ratio = 0.78, 95% confidence interval: 0.63-0.97; P = 0.02), rs4975616 (odds ratio = 0.69, 95% confidence interval: 0.55-0.85; P = 7.95 x 10(-4)), primarily for adenocarcinoma.
|
19955392 |
2010 |
|
rs2736100
|
|
|
0.100 |
GeneticVariation |
BEFREE |
DQA1*03 and the minor allele for a polymorphism, rs2736100, in TERT, another lung cancer susceptibility locus identified in recent GWASs on Europeans and Americans, were indicated to independently contribute to ADC risk with per allele OR of 1.43 (95% CI = 1.31-1.56, P = 7.8 x 10(-16)).
|
20061363 |
2010 |
|
rs2736100
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The associations between the 5p15 variants and lung cancer differed by histology; odds ratios for rs2736100 were highest in adenocarcinoma and for rs402710 were highest in adenocarcinoma and squamous cell carcinomas.
|
20548021 |
2010 |
|
rs2736100
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The combined analyses identified six well-replicated SNPs with independent effects and significant lung cancer associations (P < 5.0 × 10(-8)) located in TP63 (rs4488809 at 3q28, P = 7.2 × 10(-26)), TERT-CLPTM1L (rs465498 and rs2736100 at 5p15.33, P = 1.2 × 10(-20) and P = 1.0 × 10(-27), respectively), MIPEP-TNFRSF19 (rs753955 at 13q12.12, P = 1.5 × 10(-12)) and MTMR3-HORMAD2-LIF (rs17728461 and rs36600 at 22q12.2, P = 1.1 × 10(-11) and P = 6.2 × 10(-13), respectively).
|
21725308 |
2011 |
|
rs2736100
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The single-nucleotide polymorphisms (SNP) at 5p15 (rs2736100, adjusted odds ratio [aOR] 1.32, 95% confidence interval [CI] 1.03-1.67, P = 0.025; rs402710, aOR 0.82, 95% CI 0.69-0.98, P = 0.025; rs401681, aOR 0.82, 95% CI 0.69-0.98, P = 0.026) and at 15q25 (rs2036534, aOR 0.75, 95% CI 0.61-0.93, P = 0.01; rs6495309, aOR 0.81, 95% CI 0.65-1.00, P = 0.052) were significantly associated with lung cancer risk.
|
22404340 |
2012 |
|
rs2736100
|
|
|
0.100 |
GeneticVariation |
BEFREE |
For lung cancer, which was the most studied tumor type, the estimated joint population attributable risk for three polymorphisms (TERT rs2736100, intergenic rs4635969, and CLPTM1L rs402710) was 41%.
|
22523397 |
2012 |
|
rs2736100
|
|
|
0.100 |
GeneticVariation |
BEFREE |
After the 2nd stage validation (975 cases versus 1022 controls), the study clarified the association that rs2736100 of the TERT gene conferred the highest significant risk of lung cancer (P=4×10(-3) in the 1st stage association, P=4×10(-4) in the 2nd stage validation, and P=1×10(-5), odds ratio=1.24 in the combined population).
|
23368278 |
2013 |
|
rs2736100
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We identified one novel variant at the level corrected for multiple comparisons (rs2741354 in EPHX2 at 8p21.1 with p value = 7.4 × 10(-6)), and confirmed the associations between TERT (rs2736100) and the HLA region and lung cancer risk.
|
23370545 |
2013 |
|
rs2736100
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In addition, the rs2736100 G allele, which we previously have shown to be associated with risk of lung cancer in this cohort, was significantly associated with longer telomere length in these same study subjects (P trend = 0.030).
|
23555636 |
2013 |
|
rs2853669
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In the logistic regression analysis, TERT-rs2853669, rs2736108, and CLPTM1L-rs31490 were significant associated with increased risk of lung cancer (OR = 1.46, 95% CI = 1.22-1.75; OR = 1.22, 95% CI = 1.00-1.49 and OR = 1.74, 95% CI = 1.35-2.23 under additive model, respectively).
|
23908149 |
2013 |
|
rs2736098
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Our results suggest that the rs2736098 polymorphism may contribute to the risk of lung cancer, especially adenocarcinoma, in the Chinese population.
|
24260099 |
2013 |
|
rs2736100
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis suggests that rs2736100 is associated with the risk of lung cancer.
|
24283584 |
2013 |
|
rs2736100
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, this meta-analysis demonstrated that TERT rs2736100</span> polymorphism is a risk factor associated with increased lung cancer susceptibility, particularly for lung adenocarcinoma.
|
24390616 |
2014 |
|
rs2736100
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis suggested that TERT rs2736100 polymorphism was a risk factor for LC.
|
24535778 |
2014 |
|
rs2736100
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These data provide further evidence supporting a role for genetic susceptibility of TERT rs2736100 in the development of lung cancer.
|
24590268 |
2014 |
|
rs2736100
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Overall, significantly elevated LC risk was associated with rs2736100, rs401681, rs402710, and rs31489 polymorphisms when all studies were pooled into the meta-analysis.
|
24615522 |
2014 |
|
rs2853676
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two glioma risk variants, TERT rs2853676 and CDKN2BAS1 rs4977756, which are located in regions previously associated with lung cancer, were associated with increased risk of adenocarcinoma (OR = 1.16; 95% CI = 1.10 to 1.22; P = 1.1×10(-8)) and squamous cell carcinoma (OR = 1.13; CI = 1.07 to 1.19; P = 2.5×10(-5)), respectively.
|
24681604 |
2014 |
|
rs2736098
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The TERT rs2736098 polymorphism might affect the susceptibility to lung cancer in Chinese populations.
|
24761905 |
2014 |
|
rs2736098
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The TERT-rs2736098 T allele was also associated with increased lung cancer risk both in adenocarcinoma and squamous cell carcinoma.
|
24861918 |
2014 |
|
rs2736100
|
|
|
0.100 |
GeneticVariation |
BEFREE |
TERT polymorphism (rs2736100) might be a genetic susceptibility factor for lung cancer in non-smoking females in China.
|
25037574 |
2014 |
|
rs2853672
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two tag single-nucleotide polymorphisms were found to be associated with lung cancer risk on using the χ2-test: rs4246742 [odds ratio (OR)=0.77, 95% confidence interval (CI) 0.60-0.98; P=0.03] and rs2853672 (OR=1.26, 95% CI 1.01-1.57; P=0.045).
|
25254308 |
2014 |
|
rs4246742
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two tag single-nucleotide polymorphisms were found to be associated with lung cancer risk on using the χ2-test: rs4246742 [odds ratio (OR)=0.77, 95% confidence interval (CI) 0.60-0.98; P=0.03] and rs2853672 (OR=1.26, 95% CI 1.01-1.57; P=0.045).
|
25254308 |
2014 |