rs2922994
|
|
|
0.710 |
GeneticVariation |
BEFREE |
Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P=3.95 × 10(-15)) and HLA-B (rs2922994, P=2.43 × 10(-9)) in the HLA region significantly associated with MZL risk.
|
25569183 |
2015 |
rs9461741
|
|
|
0.710 |
GeneticVariation |
BEFREE |
Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P=3.95 × 10(-15)) and HLA-B (rs2922994, P=2.43 × 10(-9)) in the HLA region significantly associated with MZL risk.
|
25569183 |
2015 |
rs387907272
|
|
|
0.060 |
GeneticVariation |
BEFREE |
MYD88 L265P was found in 49/51 (96%) LPL cases and in 1/13 (7·6%) MZL (splenic type), whereas all CLL samples remained negative.
|
25819228 |
2015 |
rs387907272
|
|
|
0.060 |
GeneticVariation |
BEFREE |
MYD88 (L265P) somatic mutation in marginal zone B-cell lymphoma.
|
25723115 |
2015 |
rs387907272
|
|
|
0.060 |
GeneticVariation |
BEFREE |
IGHV gene features and MYD88 L265P mutation separate the three marginal zone lymphoma entities and Waldenström macroglobulinemia/lymphoplasmacytic lymphomas.
|
22944768 |
2013 |
rs387907272
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Thus, pyrosequencing for the MYD88 L265P mutation demonstrates a high clinical sensitivity and specificity to distinguish LPL from MZL and CLL.
|
26230596 |
2015 |
rs387907272
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The diagnosis of Waldenström Macroglobulinaemia (WM)/lymphoplasmacytic lymphoma (LPL) remains one of exclusion because other B-cell lymphoproliferative disorders (B-LPD), such as marginal zone lymphoma (MZL), can fulfil similar criteria, including MYD88 L265P mutation.
|
30198568 |
2019 |
rs387907272
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The most distinguishing features of LPL with respect to MZL were focal paratrabecular involvement (P < .001), the presence of lymphoplasmacytoid cells (P < .001) and Dutcher bodies (P < .001), increased numbers of mast cells (P < .001), and the MYD88 L265P mutation (P < .001).
|
25972321 |
2015 |
rs1494555
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After stratification by common B-cell lymphoma subtypes, a significant interaction was observed for IFNGR2 (rs9808753 P(forinteraction) = .006), IL13 (rs20541 P(forinteraction) = .019), and IL7R (rs1494555 P(forinteraction) = .012) for marginal zone B-cell lymphoma; IL7R (rs1494555 P(forinteraction) = .017) for small lymphocytic lymphoma/chronic lymphocytic leukemia; and IL12A (rs568408 P(forinteraction) = .013) and TNF (1799724 P(forinteraction) = .04) for follicular lymphoma.
|
20952689 |
2011 |
rs20541
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After stratification by common B-cell lymphoma subtypes, a significant interaction was observed for IFNGR2 (rs9808753 P(forinteraction) = .006), IL13 (rs20541 P(forinteraction) = .019), and IL7R (rs1494555 P(forinteraction) = .012) for marginal zone B-cell lymphoma; IL7R (rs1494555 P(forinteraction) = .017) for small lymphocytic lymphoma/chronic lymphocytic leukemia; and IL12A (rs568408 P(forinteraction) = .013) and TNF (1799724 P(forinteraction) = .04) for follicular lymphoma.
|
20952689 |
2011 |
rs344550
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, SNPs (C2 rs497309, A>C and C3 rs344550, G>C) in two complement genes were positively associated with marginal zone lymphoma (MZL) and C1QG was associated with CLL/SLL, but these results were based on a limited number of cases.
|
22170086 |
2012 |
rs3804100
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found little evidence of association between TLR2 variation and all NHL, although the rare variant rs3804100 was significantly associated with marginal zone lymphoma (MZL), both overall (OR(CT/CC) 1.89, 95% CI 1.27-2.81; P(dominant) = 0.002) and in two of the three studies.
|
19029192 |
2009 |
rs497309
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, SNPs (C2 rs497309, A>C and C3 rs344550, G>C) in two complement genes were positively associated with marginal zone lymphoma (MZL) and C1QG was associated with CLL/SLL, but these results were based on a limited number of cases.
|
22170086 |
2012 |
rs568408
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After stratification by common B-cell lymphoma subtypes, a significant interaction was observed for IFNGR2 (rs9808753 P(forinteraction) = .006), IL13 (rs20541 P(forinteraction) = .019), and IL7R (rs1494555 P(forinteraction) = .012) for marginal zone B-cell lymphoma; IL7R (rs1494555 P(forinteraction) = .017) for small lymphocytic lymphoma/chronic lymphocytic leukemia; and IL12A (rs568408 P(forinteraction) = .013) and TNF (1799724 P(forinteraction) = .04) for follicular lymphoma.
|
20952689 |
2011 |
rs77375493
|
|
|
0.010 |
GeneticVariation |
BEFREE |
JAK2 V617F mutation was present in the peripheral blood, while bone marrow biopsy revealed marginal zone B-cell lymphoma.
|
21508404 |
2011 |
rs928883
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Variant rs928883, near miR-155, showed an association (OR per A-allele: 2.80 [95% CI: 1.63-4.82]; p(F) = 0.027) with marginal zone lymphoma that is significant after correction for multiple testing.
|
22347493 |
2012 |
rs9808753
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After stratification by common B-cell lymphoma subtypes, a significant interaction was observed for IFNGR2 (rs9808753 P(forinteraction) = .006), IL13 (rs20541 P(forinteraction) = .019), and IL7R (rs1494555 P(forinteraction) = .012) for marginal zone B-cell lymphoma; IL7R (rs1494555 P(forinteraction) = .017) for small lymphocytic lymphoma/chronic lymphocytic leukemia; and IL12A (rs568408 P(forinteraction) = .013) and TNF (1799724 P(forinteraction) = .04) for follicular lymphoma.
|
20952689 |
2011 |
rs2922994
|
|
G |
0.710 |
GeneticVariation |
GWASCAT |
Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P=3.95 × 10(-15)) and HLA-B (rs2922994, P=2.43 × 10(-9)) in the HLA region significantly associated with MZL risk.
|
25569183 |
2015 |
rs9461741
|
|
C |
0.710 |
GeneticVariation |
GWASCAT |
Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P=3.95 × 10(-15)) and HLA-B (rs2922994, P=2.43 × 10(-9)) in the HLA region significantly associated with MZL risk.
|
25569183 |
2015 |
rs1107345
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Genetic overlap between autoimmune diseases and non-Hodgkin lymphoma subtypes.
|
31407831 |
2019 |
rs1250550
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Genetic overlap between autoimmune diseases and non-Hodgkin lymphoma subtypes.
|
31407831 |
2019 |
rs1323292
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Genetic overlap between autoimmune diseases and non-Hodgkin lymphoma subtypes.
|
31407831 |
2019 |
rs1364229
|
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Genetic overlap between autoimmune diseases and non-Hodgkin lymphoma subtypes.
|
31407831 |
2019 |
rs1439112
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Genetic overlap between autoimmune diseases and non-Hodgkin lymphoma subtypes.
|
31407831 |
2019 |
rs1444766
|
|
G |
0.700 |
GeneticVariation |
GWASCAT |
Genetic overlap between autoimmune diseases and non-Hodgkin lymphoma subtypes.
|
31407831 |
2019 |